Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Acute toxicity - Category 3, Inhalation
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 2
Specific target organ toxicity – repeated exposure, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
H301 Toxic if swallowed
H311 Toxic in contact with skin
H331 Toxic if inhaled
H341 Suspected of causing genetic defects
H351 Suspected of causing cancer
H373 May cause damage to organs through prolonged or repeated exposure
H411 Toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
no data available
Fresh air, rest. Refer for medical attention.
First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Rinse skin with plenty of water or shower. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!).
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Anoxia; unpleasant taste; anemia; methemoglobinemia Target Organs: Blood, liver, kidneys, cardiovascular system, spleen, bone marrow, reproductive system (NIOSH, 2016)
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Aromatic hydrocarbons and related compounds
Water may cause foaming or frothing. Use water spray, dry chemical, foam, or carbon dioxide.
This compound is combustible. (NTP, 1992)
Use water spray, powder, foam, carbon dioxide. Combat fire from a sheltered position.
Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus.
Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus.
Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Dampen spilled material with alcohol to avoid dust, then transfer material to a suitable container. Use HEPA vacuum or wet method to reduce dist during clean-up. Do not dry sweep. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Separated from combustible substances, reducing agents and food and feedstuffs. Keep in a well-ventilated room.Store in cool, dry, well-ventilated location. Separate from alkalies and oxidizing materials.
TLV: 0.1 ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued.MAK: skin absorption (H); carcinogen category: 3B
no data available
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Wear safety goggles, face shield or eye protection in combination with breathing protection if powder.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
PHYSICAL DESCRIPTION: Light yellow crystalline solid. Density 1.520 g / cm3. Melting point 83°C. Sweet odor. Very toxic by inhalation, ingestion, and skin absorption.
Monoclinic prisms
Sweet odor
82-84 °C
242 °C
Solid that does not burn, or burns with difficulty.
no data available
127 °C
no data available
no data available
no data available
1.07X10-3 Pa-s at 356.65 deg K
Insoluble in water
log Kow = 2.39
0.09 mm Hg ( 25 °C)
1.3
5.4 (vs air)
no data available
NIOSH considers p-nitrochlorobenzene to be a potential occupational carcinogen.
Decomposes on heating. This produces toxic gases of nitrogen oxides, hydrogen chloride, phosgene and chlorine. The substance is a strong oxidant. It reacts violently with combustible and reducing materials.
no data available
FIRE HAZARD SLIGHT WHEN EXPOSED TO HEAT OR FLAME.P-NITROCHLOROBENZENE reacts with oxidizing agents. Reacts violently and finally explosively when added to a solution of sodium methoxide in methanol. (NTP, 1992). Unstable when heated.
no data available
A strong oxidizer. Reacts violently with oxidizers, combustibles, alkalis, sodium methoxide, and reducing materials.
When heated to decomposition it emits veryy toxic fumes of nitrogen oxides and hydrogen chloride.
no data available
no data available
no data available
no data available
Evaluation: There is inadequate evidence in humans for the carcinogenicity of chloronitrobenzenes. There is inadequate evidence in experimental animals for the carcinogenicity of chloronitrobenzenes. Overall evaluation: Chloronitrobenzenes are not classifiable as to their carcinogenicity to humans (Group 3).
no data available
The substance may cause effects on the blood. This may result in the formation of methaemoglobin. See Notes.
Repeated or prolonged contact may cause skin sensitization.
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.
AEROBIC: 10 ug/mL 1-chloro-4-nitrobenzene inoculated with a mixed culture of microorganisms in soil was observed to be resistant to biodegradation (significant ring cleavage, as measured by UV absorbance, was not detected after 64 days)(1). 1-Chloro-4-nitrobenzene , present at 100 mg/L, reached 0 percent of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(2).
Carp exposed to solutions containing 0.15 ppm 1-chloro-4-nitrobenzene for 8 weeks had BCF values ranging from 5.8-20.9, and carp exposed to solutions containing 0.015 ppm 1-chloro-4-nitrobenzene had BCF values ranging from 7.5-18.1(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is low(SRC).
Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-chloro-4-nitrobenzene can be estimated to be 310(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-chloro-4-nitrobenzene is expected to have moderate mobility in soil(SRC).
no data available
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: UN1578 (For reference only, please check.)
IMDG: UN1578 (For reference only, please check.)
IATA: UN1578 (For reference only, please check.)
ADR/RID: CHLORONITROBENZENES, SOLID (For reference only, please check.)
IMDG: CHLORONITROBENZENES, SOLID (For reference only, please check.)
IATA: CHLORONITROBENZENES, SOLID (For reference only, please check.)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
ADR/RID: Yes
IMDG: Yes
IATA: Yes
no data available
no data available
Depending on the degree of exposure, periodic medical examination is indicated.