4-chloro-o-toluidine SDS

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H301 Toxic if swallowed

H311 Toxic in contact with skin

H331 Toxic if inhaled

H341 Suspected of causing genetic defects

H350 May cause cancer

H410 Very toxic to aquatic life with long lasting effects

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P203 Obtain, read and follow all safety instructions before use.

P273 Avoid release to the environment.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P318 IF exposed or concerned, get medical advice.

P391 Collect spillage.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Refer immediately for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer immediately for medical attention.

Inhalation, ingestion, or skin contact causes bluish tint in fingernails, lips, and ears. Headache, drowsiness, and nausea also occur. Contact with eyes causes irritation. (USCG, 1999)

14)c-labeled 4-chloro-o-toluidine, when orally admin to white rats, was degraded and eliminated primarily in urine along with radioactive metabolites. rate of absorption & degradation was slower than for chlordimeform.

Fire Extinguishing Agents: Water, dry chemical (USCG, 1999)

Special Hazards of Combustion Products: Toxic oxides of nitrogen and hydrochloric acid fumes may form. (USCG, 1999)

Use water spray, dry powder, carbon dioxide.

Sweep spilled substance into covered containers. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.

Sweep spilled substance into covered containers. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Cool. Separated from food and feedstuffs. See Chemical Dangers. Well closed. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens

MAK: skin absorption (H); carcinogen category: 1; germ cell mutagen group: 3A

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear face shield or eye protection in combination with breathing protection if powder.

Protective gloves. Protective clothing.

Use breathing protection.

no data available

Decomposes on burning. This produces toxic and corrosive fumes including hydrogen chloride and nitrogen oxides. Reacts violently with chloroformic acid esters, strong oxidants, acid anhydrides, acids and acid chlorides.

no data available

4-CHLORO-O-TOLUIDINE is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. (NTP, 1992). A halide- and amine-substituted aromatic compound. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

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Evaluation: There is sufficient evidence for the carcinogenicity of para-chloro-ortho-toluidine hydrochloride in experimental animals. There is limited evidence for the carcinogenicity of para-chloro-ortho-toluidine in humans. In formulating the overall evaluation, the Working Group took note of the fact that any salt of para-chloro-orthotoluidine with a strong acid can be expected to behave chemically in a manner similar to the hydrochloride salt in solution and in vivo. Overall evaluation: para-Chloro-ortho-toluidine and its strong acid salts are probably carcinogenic to humans (Group 2A).

no data available

May cause mechanical irritation to the skin, respiratory tract and eyes (as a solid). The substance may cause effects on the bladder. This may result in haemorrhagic inflammation. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes.

May cause heritable genetic damage to human germ cells.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

5 ppm of 14C labeled 4-chloro-o-toluidine was added to soil (pH 7.5, and organic matter, sand, silt, and clay contents of 3.4, 36.6, 28.2, and 35.2%, respectively); nearly 20% of the added 4-chloro-o-toluidine was metabolized to CO2 over a period of 40 days under aerobic conditions(1). Evolution of CO2 from the ring-labelled compound gives evidence for biologically mediated ring cleavage. Autoclaved soil control samples with added 4-chloro-o-toluidine did not produce CO2(1). Incubation of 4-chloro-o-toluidine with aniline oxidase or L-3 peroxidase obtained from the soil fungus Geotrichum candidum resulted in the formation of 2,2'-dimethyl-4,4'dichloroazobenzene through polymerizing transformations of the original compound(2). 4-Chloro-o-toluidine from a petrochemical industrial process wastewater at an initial concentration of 110 mg/l with activated sludge as an inoculum and a one day acclimation period gave 16% removal by measuring COD(Mn) and 7% removal of TOC after a 24 hour period under aerobic conditions(3). This compound was considered to be non-biodegradable using this test(3). Gas chromatography however, used to measure biodegradation during this same 24 hour period, showed better degradability of 4-chloro-o-toluidine suggesting that structural breakdown of this compound occurs prior to oxidation of carbon into carbon dioxide(3). 0% biodegradation of 4-chloro-o-toluidine was shown via BOD in a 2 week experiment using activated sludge as an inoculum and with 4-chloro-o-toluidine present at 100 mg/ml(4).

Bioconcentration of 4-chloro-o-toluidine was measured in carp over a 6 week time period. At concentrations of 0.34 mg/ml and 0.034 mg/ml 4-chloro-o-toluidine, BCF values of 7.7-12 and <35 respectively, were reported(1). These values suggest that bioconcentration of 4-chloro-o-toluidine in aquatic organisms is not an important fate process for this compound(SRC).

The Koc for 4-chloro-o-toluidine was estimated as 410(SRC), using a recommended regression-derived equation(1) and an estiamted log Kow of 2.27(2,SRC). According to a suggested classification scheme(3), this estimated Koc value suggests that 4-chloro-o-toluidine has moderate mobility in soil(SRC). 14C labelled 4-chloro-o-toluidine was added to autoclaved soil (pH 7.5, and organic matter, sand, silt, and clay contents of 3.4, 36.6, 28.2, and 35.2%, respectively) and incubated for several weeks; 12.2% of the radioactive label was removed as volatiles, 25% was recovered in a Soxhlet extract, and 55.1% of the radioactive label was obtained after Soxhlet extraction using Bleidner distillation (bound residue fraction)(4). This suggests that a significant portion of the 4-chloro-o-toluidine is bound strongly by this soil(4). Over a 24 hour time period, 34% of applied 4-chloro-o-toluidine was found in the bound residue fraction(5). Binding due to the high reactivity of the aromatic amino group to humus or soil organic matter rather than to clay particles is proposed as a reason for the soil binding ability of anilines(4,5). Low adsorption is observed at a neutral pH with pure clay minerals or soils for substituted anilines(5).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2239 (For reference only, please check.)

IMDG: UN2239 (For reference only, please check.)

IATA: UN2239 (For reference only, please check.)

ADR/RID: CHLOROTOLUIDINES, SOLID (For reference only, please check.)

IMDG: CHLOROTOLUIDINES, SOLID (For reference only, please check.)

IATA: CHLOROTOLUIDINES, SOLID (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: III (For reference only, please check.)

IMDG: III (For reference only, please check.)

IATA: III (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Depending on the degree of exposure, periodic medical examination is suggested.Do NOT take working clothes home.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.