4-amino-2-nitrophenol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 4-amino-2-nitrophenol
- CAS： 119-34-6
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Warning
H302 Harmful if swallowed
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
none
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 4-amino-2-nitrophenol
- Common names and synonyms: 4-amino-2-nitrophenol
- CAS number: 119-34-6
- EC number: 204-316-1
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, upper respiratory tract and mucous membranes; and methemoglobinemia. ACUTE/CHRONIC HAZARDS: This material can cause irritation of the skin, eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and NOx. (NTP, 1992)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Aniline and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers. Poisonous gases are produced in fire including nitrogen oxides. If materials or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local healty and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position.
Specific hazards arising from the chemical
Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Evacuate persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Dampen spilled material with 60 to 70% acetone to avoid airborne dust and remove to sealed containers for disposal. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped.
SECTION 7: Handling and storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Prior to working with this chemical you should be trained on its proper handling and storage. Store in cool, dry place away from air and away from mineral acids and bases
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
PHYSICAL DESCRIPTION: Dark red plates, needles or reddish-purple powder. Melting point 125-127°C.
-
Colour：
Dark-red plates or needles from water and ethanol
-
Odour：
no data available
-
Melting point/freezing point：
251°C(lit.)
-
Boiling point or initial boiling point and boiling range：
262°C(lit.)
-
Flammability：
no data available
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
35°C(lit.)
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
less than 0.1 mg/mL at 70° F (NTP, 1992)
-
Partition coefficient n-octanol/water：
log Kow = 0.96
-
Vapour pressure：
6.57E-05mmHg at 25°C
-
Density and/or relative density：
1.511 g/cm3
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Sensitive to oxidation upon prolonged exposure to air. Insoluble in water.
Chemical stability
no data available
Possibility of hazardous reactions
4-AMINO-2-NITROPHENOL may react with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides (NTP, 1992).
Conditions to avoid
no data available
Incompatible materials
Strong oxidizers, mineral acids, strong bases.
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of nitrogen oxides.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 3300 mg/kg In oil-water emulsion
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
No data are available in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 Pimephales promelas (fathead minnow) 34.3 (29.9-39.4) mg/L 96 hr, wt 150 mg, flow-through bioassay, dissolved oxygen 7.4 (4.6-8.8) mg/L, water hardness 44.9 (42.4-46.6) mg/L as CaCO3, pH 6.9-7.7, alkalinity 42.9 (39.6-61.4) mg/L CaCO3, temp: 26.4 + or - 1.4 deg C, Purity 97%
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
PURE CULTURE: 4-Amino-2-nitrophenol (0.025% w/v) was used as a carbon source for Nocardia v. when measured for visible growth over a period of 16 days at 30 deg C(1); growth was slight but noticeable.
Bioaccumulative potential
An estimated BCF of 3 was calculated for 4-amino-2-nitrophenol(SRC), using a log Kow of 0.96(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of 4-amino-2-nitrophenol is estimated as 79(SRC), using a log Kow of 0.96(1)and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 4-amino-2-nitrophenol is expected to have high mobility in soil. The pKa of 4-amino-2-nitrophenol is 7.81 (phenol)(4), indicating that this compound will partially exist in anion form in the environment, and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). However, anilines may bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(6,7), suggesting that mobility may be much lower in some soils(SRC).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN1760 (For reference only, please check.)
IMDG: UN1760 (For reference only, please check.)
IATA: UN1760 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CORROSIVE LIQUID, N.O.S. (For reference only, please check.)
IMDG: CORROSIVE LIQUID, N.O.S. (For reference only, please check.)
IATA: CORROSIVE LIQUID, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 8 (For reference only, please check.)
IMDG: 8 (For reference only, please check.)
IATA: 8 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/