Acute toxicity - Category 4, Oral
Specific target organ toxicity – single exposure, Category 1
H302 Harmful if swallowed
H370 Causes damage to organs
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P308+P316 IF exposed or concerned: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
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Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
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Treatment of metoclopramide overdosage generally involves symptomatic and supportive care. There is no specific antidote for metoclopramide intoxication; however, agents with central anticholinergic activity (eg, diphenhydramine, benztropine) may be useful in controlling extrapyramidal reactions. Following acute ingestion of the drug, the stomach should be emptied immediately. If the patient is comatose, having seizures, or lacks the gag reflex, gastric lavage may be performed if an endotracheal tube with cuff inflated is in place to prevent aspiration of gastric contents. Symptoms of metoclopramide overdosage are generally self-limiting and usually subside within 24 hours. Appropriate therapy should be instituted if hypotension or excessive sedation occurs. Methemoglobinemia should be treated with methylene blue. However, in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, methylene blue can induce hemolytic anemia, which may be fatal. Hemodialysis or peritoneal dialysis is unlikely to enhance the elimination of metoclopramide.
Water spray, dry chemical, carbon dioxide or foam as appropriate for surrounding fire and materials.
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Wear self-contained breathing apparatus for firefighting if necessary.
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Wear approved respiratory protection, chemically compatible gloves and protective clothing. Wipe up spillage or collect spillage using a high efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately labelled container for disposal. Wash spill site.
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Metoclopramide hydrochloride tablets, injection, and oral solution should be stored at controlled room temperature between 20-25 deg C. Metoclopramide hydrochloride tablets and metoclopramide hydrochloride oral solution should be stored in tight, light-resistant containers (ie, amber glass bottles).
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Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
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Solid
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-46°C(lit.)
342°C(lit.)
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96°C(lit.)
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4.6X10-9 mm Hg at 25 deg C (est)
1.162 g/cm3
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Metoclopramide hydrochloride is photosensitive and will degrade when exposed to light. Commercially available preparations of metoclopramide hydrochloride should be protected from light. The commercially available tablets are stable for 3 years and the oral solution and injection are stable for 5 years after manufacture.
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Incompattable with/ strong alkalis, strong oxidizing agents.
When heated to decomposition it emits very toxic fumes of /nitrogen oxides and hydrogen chloride/.
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An estimated BCF of 25 was calculated in fish for metoclopramide(SRC), using a log Kow of 2.62(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
The Koc of metoclopramide is estimated as 120(SRC), using a log Kow of 2.62(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that metoclopramide is expected to have high mobility in soil. The pKa of metoclopramide is 9.27(4), indicating that this compound will almost entirely exist in the cation form in the environment and cations generally do adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).
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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
ADR/RID: Not dangerous goods. (For reference only, please check.)
IMDG: Not dangerous goods. (For reference only, please check.)
IATA: Not dangerous goods. (For reference only, please check.)
ADR/RID: No
IMDG: No
IATA: No
no data available
no data available