Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Skin irritation, Category 2
Eye irritation, Category 2
Acute toxicity - Category 3, Inhalation
Specific target organ toxicity – repeated exposure, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
H301 Toxic if swallowed
H311 Toxic in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
H331 Toxic if inhaled
H373 May cause damage to organs through prolonged or repeated exposure
H400 Very toxic to aquatic life
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
no data available
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .
SYMPTOMS: Symptoms of exposure to this chemical may include methemoglobinemia and, in large concentrations cyanosis; dermatitis, liver and kidney damage, and death. ACUTE/CHRONIC HAZARDS: This compound can cause allergic reactions. It is readily absorbed through the skin. When heated to decomposition it emits toxic fumes. (NTP, 1992)
Methylene blue, alone or in combination with oxygen, is indicated as treatment in nitrite-induced methemoglobinemia.
Water, dry chemical, foam or carbon dioxide. 4-Chloroaniline
This chemical is combustible. (NTP, 1992)
Use powder, AFFF, foam, carbon dioxide.
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Separated from food and feedstuffs. Keep in the dark. Well closed.
MAK skin absorption (H); MAK sensitization of skin (SH)
no data available
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Wear safety goggles or face shield.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
Liquid.
Colourless.
Characteristic sweet odor
-10.28 °C. Remarks:Other details not available.
168.8 °C. Atm. press.:960 hPa.
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
no data available
110 °C. Atm. press.:960 hPa.
Atm. press.:960 hPa. Remarks:3-Chloroaniline did not catch fire on being exposed to air at room temperature of 30 degC.
230°C
8.02. Remarks:Basic.
dynamic viscosity (in mPa s) = 19.414. Temperature:30.0°C. Remarks:16.37 cst (centistoke ) when converted into mPa s (dynamic) is equivalent to 19.414.
Insoluble in water
Pow = 5.89. Temperature:30 °C.
8.799 Pa. Temperature:25 °C.
1.186 g/cm3. Temperature:30 °C.
4.41 (NTP, 1992) (Relative to Air)
no data available
Decomposes on burning. This produces toxic fumes including nitrogen oxides and hydrogen chloride (see ICSC 0163).
Tends to darken during storage.
M-CHLOROANILINE is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. (NTP, 1992)
no data available
no data available
When heated to decomposition, it emits toxic fumes of /hydrogen chloride and nitrogen oxides/.
no data available
no data available
no data available
no data available
no data available
no data available
The substance is irritating to the eyes and skin. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Medical observation is indicated. The effects may be delayed.
The substance may have effects on the blood. This may result in the formation of methaemoglobin.
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
AEROBIC: In a test using a Warburg respirometer, 50% of the theoretical BOD was measured for 3-chloroaniline over a 190 hr incubation period(1). A 100% loss of UV absorbance of 3-chloroaniline in a mineral salts solution, with a soil inoculum, required an excess of 64 days(2). Using an acclimated activated sludge inoculum, 97.2% of initial 3-chloroaniline was degraded under the test conditions(3). Biological transformation (20% degradation in 6 hr) was observed in an aqueous test system receiving activated sludge from two treatment plants(4). In the Zahn-Wellens test, 100% DOC removal was obtained in 17 days(7). Incubation of 3-chloroaniline (50 mg/50 g soil) in soil for 14 days resulted in formation of 3,3'-dichloroazobenzene(5). No dichloroazobenzene was formed using sterilized soil(5). 3-Chloroaniline was degraded (85-90%) with no lag period by a mixed culture of containing Pseudomonas (12 species) and Bacillus (15 species), which was isolated from sludge that was acclimated to nitroaniline(6). 3-Chloroaniline may degrade in soil by chemical and microbial processes(8). When 3-chloroaniline (30 ppm) was incubated in Guelph loam with water added to 60% water-holding capacity, levels declined rapidly for 2 weeks after which time the rate of loss decreased(8). The percent of 3-chlororaniline remaining in soil after 2 and 8 weeks were 38% and 18%, respectively(8).
The average BCFs in the whole body of carp exposed to 3-chloroaniline in flow-through experiments (25 deg C, 12 L/hr) for 24 to 336 hr at high (14.7 ug/L) and low (0.67 ug/L) exposure levels were 0.8 and 2.2, respectively(1). Excretion was rapid with depuration rates and half-lives of 0.21/hr and 3.3 hr, respectively(1). This conclusion is supported by field data in which the concentration of 3-chloroaniline in water and fish were <0.02 - 0.02 ug/L and <2.0 ng/g(1). Uptake was rapid in static tests (0.17 umol/L, 26 deg C) on zebrafish and a BCF of 11.5 was obtained for 100 hr exposure (2). Elimination was best described by a two compartment first order model(2). After 52 hr of depuration, the concn of 3-chloroaniline in the zebrafish declined to 10.3% of the steady state value. According to a classification scheme(3), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).
The Koc of 3-chloroaniline is estimated as 250(SRC), using a log Kow of 1.88(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 3-chloroaniline is expected to have moderate mobility in soil. However, aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(4,5), suggesting that mobility may be much lower in some soils(SRC). In laboratory persistence studies using non-sterilized Hagerstown silty clay loam soil, 73% of applied 3-chloroaniline remained chemically bound to soil particles after 64 days of incubation(6). A related chemical, 2-chloroaniline, has been observed to undergo rapid and reversible covalent bonding with humic materials in aqueous solution; the initial bonding reaction is followed by a slower and much less reversible reaction believed to represent the addition of the amine to quinoidal structures followed by oxidation of the product to give an amino-substituted quinone(7).
no data available
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
ADR/RID: UN2019 (For reference only, please check.)
IMDG: UN2019 (For reference only, please check.)
IATA: UN2019 (For reference only, please check.)
ADR/RID: CHLOROANILINES, LIQUID (For reference only, please check.)
IMDG: CHLOROANILINES, LIQUID (For reference only, please check.)
IATA: CHLOROANILINES, LIQUID (For reference only, please check.)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
ADR/RID: Yes
IMDG: Yes
IATA: Yes
no data available
no data available
Stabilized with 0.1% Hydrazine hydrate.Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.