2-methoxyethanol SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： 2-methoxyethanol
- CAS： 109-86-4
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Flammable liquids, Category 3
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Acute toxicity - Category 4, Inhalation
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H226 Flammable liquid and vapour
H302 Harmful if swallowed
H312 Harmful in contact with skin
H332 Harmful if inhaled
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.
P242 Use non-sparking tools.
P243 Take action to prevent static discharges.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower].
P370+P378 In case of fire: Use ... to extinguish.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P318 IF exposed or concerned, get medical advice.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: 2-methoxyethanol
- Common names and synonyms: 2-methoxyethanol
- CAS number: 109-86-4
- EC number: 203-713-7
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Fresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .
Most important symptoms/effects, acute and delayed
Irritation of skin and eyes. Chronic exposure may also cause weakness, sleepiness, headache, gastrointestinal upset, weight loss, change of personality. (USCG, 1999)
Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Ethylene glycol, glycols, and related compounds
SECTION 5: Firefighting measures
Suitable extinguishing media
Use water spray, powder, alcohol-resistant foam, carbon dioxide.
Specific hazards arising from the chemical
Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)
Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.
Environmental precautions
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames, NO sparks and NO smoking. Above 39°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Fireproof. Separated from strong oxidants and food and feedstuffs. Keep in the dark. Cool.Fireproof. Separated from strong oxidants and food and feedstuffs. Keep in the dark. Cool.
SECTION 8: Exposure controls/personal protection
Control parameters
TLV: 0.1 ppm as TWA; (skin); BEI issued.MAK: 3.2 mg/m3, 1 ppm; peak limitation category: II(8); skin absorption (H); pregnancy risk group: B.EU-OEL: 1 ppm as TWA; (skin)
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Liquid.
-
Colour：
Colourless.
-
Odour：
Mild agreeable odor
-
Melting point/freezing point：
<= -85.1 °C. Atm. press.:1 atm.
-
Boiling point or initial boiling point and boiling range：
>= 124.34 °C. Atm. press.:Ca. 760 mm Hg.
-
Flammability：
Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.
-
Lower and upper explosion limit/flammability limit：
2.5%-19.8% (in air)
-
Flash point：
42 °C. Atm. press.:1 atm.
-
Auto-ignition temperature：
285 °C. Atm. press.:1 atm.
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
dynamic viscosity (in mPa s) = 1.72. Temperature:20°C.
-
Solubility：
Miscible with water
-
Partition coefficient n-octanol/water：
log Pow = -0.77. Temperature:28 °C.
-
Vapour pressure：
9.5 mm Hg. Temperature:25 °C. Remarks:Equivalent to 12.7 hPa at 25 C.
-
Density and/or relative density：
Ca. 0.97 g/cm3. Temperature:20 °C.
-
Relative vapour density：
2.62 (vs air)
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
The substance can form explosive peroxides. Reacts with strong oxidants. This generates fire and explosion hazard. Attacks some forms of plastic and coatings.
Chemical stability
Heat contributes to instability
Possibility of hazardous reactions
FlammableETHYLENE GLYCOL MONOMETHYL ETHER is incompatible with oxygen and strong oxidizing agents. Contact with bases may result in decomposition. Incompatible with acid chlorides and acid anhydrides. (NTP, 1992). It forms explosive peroxides.
Conditions to avoid
no data available
Incompatible materials
Ethylene glycol monomethyl ether /in air/ forms peroxides that are highly explosive.
Hazardous decomposition products
Thermal decomposition 204 - 232 deg C
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - 2 257 mg/kg bw. Remarks:Results for fasted animals.
- Inhalation: LC0 - rat (male) - > 15.8 mg/L air.
- Dermal: LD50 - rabbit (male) - 3 930 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system, blood, bone marrow, kidneys and liver. Exposure at high levels could cause unconsciousness. Medical observation is indicated.
STOT-repeated exposure
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the blood and bone marrow. This may result in anaemia and lesions of blood cells. May cause toxicity to human reproduction or development.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50 - Lepomis macrochirus - > 10 000 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 27 000 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - 25 500 mg/L - 72 h.
- Toxicity to microorganisms: EC50 - activated sludge of a predominantly domestic sewage - > 1 000 mg/L - 3 h. Remarks:Respiration rate.
Persistence and degradability
AEROBIC: Biodegradation of 2-methoxyethanol (100-1000 mg/L) with activated sludge at 20 degrees C for 10 days resulted in 64.7% theoretical BOD(1). Biodegradation of 2-methoxyethanol at 3, 7, and 10 mg/L with filtered sewage seed in fresh water resulted in 30% theoretical BOD in 5 days and 88% theoretical BOD in 20 days; in salt water 6% theoretical BOD in 5 days and 39% theoretical BOD in 20 days was observed(2). Sewage seed degraded 2-methoxyethanol over 5 days resulting in 7% theoretical BOD using unadapted seed and 30% theoretical BOD using adapted seed(3). 2-Methoxyethanol, present at 100 mg/L, reached 83-94% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese Ministry of Trade and Industry (MITI) test(4).
Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for 2-methyoxyethanol(SRC), using a log Kow of -0.77(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of 2-methoxyethanol is estimated as 1(SRC), using a log Kow of -0.77(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2-methoxyethanol is expected to have very high mobility in soil(SRC).
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN1188 (For reference only, please check.)
IMDG: UN1188 (For reference only, please check.)
IATA: UN1188 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ETHYLENE GLYCOL MONOMETHYL ETHER (For reference only, please check.)
IMDG: ETHYLENE GLYCOL MONOMETHYL ETHER (For reference only, please check.)
IATA: ETHYLENE GLYCOL MONOMETHYL ETHER (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 3 (For reference only, please check.)
IMDG: 3 (For reference only, please check.)
IATA: 3 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Depending on the degree of exposure, periodic medical examination is indicated.The odour warning when the exposure limit value is exceeded is insufficient.Check for peroxides prior to distillation; eliminate if found.