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HomecompanyEsomeprazole Sodium/Esomeprazole Sodium Impurity with Best Price Pharmaceutical Intermediates
Esomeprazole sodium
Esomeprazole sodium
Esomeprazole sodium
Esomeprazole sodium
Esomeprazole sodium
Esomeprazole sodium

Esomeprazole Sodium/Esomeprazole Sodium Impurity with Best Price Pharmaceutical Intermediates

Price USD10.00USD15.00USD20.00
Packge 1kg1kg1kg
  • Min. Order:1kg
  • Supply Ability:100000ton/Years
  • Time:2022-06-30

Product Details

  • Product NameEsomeprazole sodium
  • CAS No.161796-78-7
  • EINECS No.620-470-6
  • MFC34H36MgN6O6S2
  • MW713.12
  • AppearanceSolidPale Beige to Brown
  • Melting point 156 °C (approx)
  • storage temp. Inert atmosphere,Store in freezer, under -20°C

Basic Info.

Model NO.
161796-78-7
Colour
White
Transport Package
1kg/Foil Box
Specification
20*15*13
Trademark
LINWO
Origin
China
HS Code
2934999090
Production Capacity
100000ton/Years

Product Description

USP 99% High Quality Pharmaceutical Material Esomeprazole Sodium CAS 161796-78-7

Introduction 

                                    Name
Esomeprazole sodium
Synonyms
5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl-1H-benzimidazole sodium salt

Molecular Structure


Molecular Formula
C17H20N3NaO3S
Molecular Weight
369.41
CAS Registry Number
161796-78-7

Esomeprazole is in a group of drugs called proton pump inhibitors. Esomeprazole decreases the amount of acid produced in the stomach.

Esomeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Esomeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Esomeprazole sodium is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.IC50 value:Target: proton pumpEsomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis. Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.

Function

Esomeprazole sodium is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome.

Specification

Test items

Specifications

Result

Appearance

White or slightly coloured powder,slight hygroscopic

almost white powder

Identification

A. IR

B.Enantiomeric purity

C.Reaction of maganesium

D. Water

 

IR Conforms to the CRS.(2.2.24)

Impurity F  ≤0.2%(2.2.29)

It gives reaction of magnesium(2.3.1)

6.2%~8.0%(2.5.12)

 

Complies

0.05%

Complies

7.3%

Absorbance

The absorbance is not greater than 0.20 at 440nm.(2.2.25)

0.12

Related substances(HPLC)

Impurity E

Impurity D

Unspecified  impurities

Total impurity

 Impurity F 

(2.2.29)

≤0.15%

≤0.15%

≤0.10%

≤0.3%

≤0.2%(2.2.29)

 

0.04%

0.10%

0.03%

0.2%

0.05%

Magnesium

3.30%~3.55%

3.46%

Water by K.F.

6.2%~8.0%(2.5.12)

7.3%

Assay(HPLC)

98.0%~102.0%(2.2.29)

99.9%

Residual solvents:

a) Acetne

b)Etyl aetate

c)Methylene chloide

d)Methnol

e)Toluee

f)Benzene

 

Not more than 5000ppm

Not more than 5000ppm

Not more than 100ppm

Not more than 3000ppm

Not more than 890ppm

Not more than 2ppm

 

3ppm

Not detected

Not detected

77ppm

Not detected

Not detected

Chemical & Physical Properties

 
Boiling Point600ºC at 760 mmHg
Molecular FormulaC17H18N3NaO3S
Molecular Weight367.398
Flash Point316.7ºC
Exact Mass367.096649
PSA85.45000
LogP3.55120

Store in a cool and ventilated warehouse. Keep away from fire and heat source. The storage temperature should not exceed 32 ºC, and the relative humidity should not exceed 80%. Keep away from light. The package shall be sealed and shall not come into contact with air. Provide corresponding varieties and quantities of fire-fighting equipment. The storage area shall be equipped with leakage emergency treatment equipment and appropriate receiving materials.


Company Profile Introduction

New material technology research and development、Technology popularization、 Technical consulting、Technology transfer、Medical technology r&d
  • Since:2022-03-18
  • Address: Room 601, Unit 1, Building 1, 188 Xinhuali, North Xinhua Road, Xiangdu District, Xingtai city, Hebei
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