ALX 0600

Product Name: ALX 0600

Synonyms: ALX 0600;Gattex;Glucagon-like peptide II [2-glycine] (human);Teduglutide

CAS: 197922-42-2

MF: C164H252N44O55S

MW: 3752.08248

EINECS:

Product Categories:

Mol File: 197922-42-2.mol

ALX 0600 Structure

ALX 0600 Chemical Properties

Safety Information

MSDS Information

ALX 0600 Usage And Synthesis

Description Teduglutide was approved in August 2012 by the European Commission and in December 2012 by the US FDA for the treatment of adults with short bowel syndrome (SBS) who are dependent on parenteral nutrition (PN). Teduglutide (also known as ALX-0600) is a GLP-2 analogue in which glycine has been substituted for alanine at position 2 from the N-terminus, thereby conferring resistance to degradation by DPP-4. Teduglutide has similar binding affinity, agonist potency, and agonist efficacy as GLP-2 in assays with the rat GLP-2 receptor. Administration of teduglutide to rats gave a significant increase in small intestine weight and an increase in the height of intestinal villi. Teduglutide was prepared by solid-phase peptide synthesis.

Originator NPS Allelix (Canada)

Uses Treatment of intestinal diseases characterized by chemical or surgical damage of the intestinal epithelium such as Short Bowel Syndrome (SBS) or damage to the intestinal epithelium due to disease (glucagon-like peptide-2 (GLP- 2) analog).

Definition ChEBI: A 33-membered polypeptide consisting of His, Gly, Asp, Gly, Ser, Phe, Ser, Asp, Glu, Met, Asn, Thr, Ile, Leu, Asp, Asn, Leu, Ala, Ala, Arg, Asp, Phe, Ile, Asn, Trp, Leu, Ile, Gln, Thr, Lys, Ile, Thr and Asp residues joined in sequence. A glucagon-like pep ide-2 receptor agonist used for the treatment of short-bowel syndrome.

Brand name Gattex