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Price	USD3.00
Packge	1KG

Min. Order:1KG
Supply Ability:1kg,5kg,50kg
Time:2020-01-19

Product Details

Product NameCorynoline
CAS No.18797-79-0
MFC21H21NO5
MW367.4
AppearanceSolidOff-White to Pale Yellow
Melting point 180～181℃
Boiling point 504.2±50.0 °C(Predicted)
density 1.395±0.06 g/cm3(Predicted)
storage temp. Amber Vial, -20°C Freezer, Under inert atmosphere

Names

Name Corynoline

Synonym More Synonyms

Corynoline Biological Activity

Description Corynoline, isolated from Corydalis incise (Papaveraceae), is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].

Related Catalog

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

References

[1]. Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25(6):817-9.

[2]. Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41(5):1640-1647.

Chemical & Physical Properties

Density 1.4±0.1 g/cm3

Boiling Point 504.2±50.0 °C at 760 mmHg

Melting Point 217-218ºC

Molecular Formula C21H21NO5

Molecular Weight 367.395

Flash Point 258.7±30.1 °C

Exact Mass 367.141968

PSA 60.39000

LogP 3.23

Vapour Pressure 0.0±1.4 mmHg at 25°C

Index of Refraction 1.659

Safety Information

Symbol GHS06

GHS06

Signal Word Danger

Hazard Statements H300 + H330

Precautionary Statements P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233

Safety Phrases 24/25

RIDADR UN 1544PSN1 6.1 / PGII

Precursor & DownStream

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

career henan chemical co

Henan China

Since:2014-12-17
Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H

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