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Price	USD3.00
Packge	1KG

Min. Order:1KG
Supply Ability:1kg,5kg,50kg
Time:2020-01-19

Product Details

Product NameCyasterone
CAS No.17086-76-9
MFC29H44O8
MW520.65
AppearancePowderWhite to off-white
Melting point 164～166℃
Boiling point 735.2±60.0 °C(Predicted)
density 1.31±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C

Names

Name cyasterone

Synonym More Synonyms

Cyasterone Biological Activity

Description Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae).Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a clinical therapeutic anti-tumor agent against human tumors[1].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

In Vitro Cyasterone (0-100μM; 24hours) inhibits cell growth in a concentration-and time-dependent manner, IC50 values are 38.50 mg/mL, 32.96 mg/mL in A549 and MGC823 cells ,respectively[1]. Cell Viability Assay[1] Cell Line: A549, HCT116, MGC823 cells Concentration: 0-100 μM Incubation Time: 24 hours Result: Inhibited the growth of 3 human cancer lines A549, HCT116, MGC823 cells.

References

[1]. Lu X, et al. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother. 2016 Dec;84:330-339.

Chemical & Physical Properties

Density 1.3±0.1 g/cm3

Boiling Point 742.8±60.0 °C at 760 mmHg

Molecular Formula C29H44O8

Molecular Weight 520.655

Flash Point 242.0±26.4 °C

Exact Mass 520.303589

PSA 144.52000

LogP -0.25

Vapour Pressure 0.0±5.6 mmHg at 25°C

Index of Refraction 1.600

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :

WJ2510000

CHEMICAL NAME :

5-beta-Stigmast-7-en-26-oic acid, 2-beta,3-beta,14,20,22,28-hexahydroxy-6-oxo-, gamma- lactone, (22R,24S,25S,28R)-

CAS REGISTRY NUMBER :

17086-76-9

LAST UPDATED :

198909

DATA ITEMS CITED :

MOLECULAR FORMULA :

C29-H44-O8

MOLECULAR WEIGHT :

520.73

WISWESSER LINE NOTATION :

L E5 B666 LV JUTJ IQ OQ PQ FXQ1&YQ1YYQ1&Y1&- CT4OVTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :

Insect - Drosophila melanogaster

DOSE/DURATION :

300 umol/L

REFERENCE :

NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246, 1971-73. For publisher information, see NATUAS. Volume(issue)/page/year: 230,222,1971

Safety Information

Safety Phrases 24/25

RIDADR NONH for all modes of transport

RTECS WJ2510000

Synonyms

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

career henan chemical co

Henan China

Since:2014-12-17
Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H

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