summer@coreychem.com

Price	USD3.00
Packge	1KG

Min. Order:1KG
Supply Ability:1kg,5kg,50kg
Time:2020-01-19

Product Details

Product NameLicofelone
CAS No.156897-06-2
EINECS No.694-581-3
MFC23H22ClNO2
MW379.88
AppearanceSolidOff-White to Light Yellow
density 1.23
Melting point 162-163°C
storage temp. -20°C Freezer
Boiling point 539.7±50.0 °C(Predicted)

Names

Name Licofelone

Synonym More Synonyms

Licofelone Biological Activity

Description Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor for the treatment of osteoarthritis. Licofelone (ML-3000) exerts anti-inflammatory and anti-proliferative effects. Licofelone (ML-3000) induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[1][2].

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> COX

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

References

[1]. Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29(2):371-80.

[2]. Alvaro-Gracia JM, et al. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford). 2004 Feb;43 Suppl 1:i21-5.

Chemical & Physical Properties

Density 1.2±0.1 g/cm3

Boiling Point 539.7±50.0 °C at 760 mmHg

Melting Point 162-163ºC

Molecular Formula C23H22ClNO2

Molecular Weight 379.879

Flash Point 280.2±30.1 °C

Exact Mass 379.133911

PSA 42.23000

LogP 6.73

Vapour Pressure 0.0±1.5 mmHg at 25°C

Index of Refraction 1.627

Storage condition -20°C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :

UY7759650

CHEMICAL NAME :

1H-Pyrrolizine-5-acetic acid, 2,3-dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-

CAS REGISTRY NUMBER :

156897-06-2

LAST UPDATED :

199612

DATA ITEMS CITED :

MOLECULAR FORMULA :

C23-H22-Cl-N-O2

MOLECULAR WEIGHT :

379.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>300 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,159,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1100 mg/kg/11D-I

TOXIC EFFECTS :

Gastrointestinal - ulceration or bleeding from duodenum

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1329,1994

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

career henan chemical co

Henan China

Since:2014-12-17
Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H

INQUIRY