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Homecompany3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol

3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol

Price USD1.00
Packge 1g
  • Min. Order:1g
  • Supply Ability:1ton
  • Time:2020-01-13

Product Details

  • Product Name3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
  • CAS No.164658-13-3
  • EINECS No.200-258-5
  • MFC18H18ClN5O
  • MW355.82
  • AppearancePowderLight yellow to yellow
  • density 1.356
  • Melting point 144-147℃
  • Boiling point 630.6±65.0 °C(Predicted)
  • storage temp. 2-8°C(protect from light)
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Common Name
3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
CAS Number
164658-13-3
Molecular Weight
355.82100
Density
1.356g/cm3
Boiling Point
630.6ºC at 760mmHg
Molecular Formula
C18H18ClN5O
Melting Point
N/A
MSDS
N/A
Flash Point
335.2ºC
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 Use of 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol

 
CGP60474 is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM, and also an ATP-competitive PKC inhibitor.

 Names

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Name
3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol
Synonym
More Synonyms

  Biological Activity

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Description
CGP60474 is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM, and also an ATP-competitive PKC inhibitor.
Related Catalog
Target

VEGFR-2:84 nM (IC50)

PKC

In Vitro
CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM[1]. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP[2].
References

[1]. Kuo GH, et al. Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors. J Med Chem. 2005 Jul 14;48(14):4535-46.

[2]. Stanetty P, et al. Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J Org Chem. 2005 Jun 24;70(13):5215-20.

 Chemical & Physical Properties

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Density
1.356g/cm3
Boiling Point
630.6ºC at 760mmHg
Molecular Formula
C18H18ClN5O
Molecular Weight
355.82100
Flash Point
335.2ºC
Exact Mass
355.12000
PSA
86.19000
LogP
3.22480
Vapour Pressure
9.02E-17mmHg at 25°C
Index of Refraction
1.685

 Synonyms

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GNF-Pf-88
1-Propanol,3-((4-(2-((3-chlorophenyl)amino)-4-pyrimidinyl)-2-pyridinyl)amino)
UNII-16IP6G5MLC
CGP60474
Top Suppliers:I want be here
  • Absin Bioscience Inc
  • China
  • Product Name: CGP60474
  • Price:￥1210.0/5mg￥1892.0/10mg￥7040.0/50mg
  • Purity: 98.0%
  • Stocking Period: 7 Day
  • Contact: jenny zhou

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

Recommended supplier

career henan chemical co

Henan China
  • Since:2014-12-17
  • Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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