Pyraclofos

Pyraclofos Basic information
Product Name: Pyraclofos
Synonyms: （RS）-O-ethyl-S-propyl-O-[1-(4-chlorophenyl) pyrazol-4-yl] phosphorothioate;OMS3034;SC 1069;TIA 230;1-(4-Chlorophenyl)-4-(ethoxy-propylsulfanylphosphoryl)oxypyrazole;Phosphorothioic acid, O-[1-(4-chlorophenyl)-1H-pyrazol-4-yl] O-ethyl S-propyl ester;Pyraclofos 50mg [77458-01-6];Pyraclofos Solution, 100ppm
CAS: 77458-01-6
MF: C14H18ClN2O3PS
MW: 360.8
EINECS:
Product Categories: Pyrazoles;Alpha sort;Insecticides;N-PPesticides;OrganophorousAlphabetic;P;Pesticides&Metabolites;PU - PZPesticides
Mol File: 77458-01-6.mol
Pyraclofos Structure
Pyraclofos Chemical Properties
Melting point 25°C
Boiling point 164approximate 164℃(0.013hPa)
density 1.27
vapor pressure 1.6×10-6 Pa (20 °C)
storage temp. 0-6°C
form liquid
Water Solubility 33
Specific Gravity 1.271 (28℃)
CAS DataBase Reference 77458-01-6(CAS DataBase Reference)
EPA Substance Registry System Phosphorothioic acid, O-[1-(4-chlorophenyl)-1H-pyrazol- 4-yl] O-ethyl S-propyl ester(77458-01-6)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 22
RIDADR 3018
RTECS TE8346000
HazardClass 6.1(b)
PackingGroup III
HS Code 29331990
MSDS Information
Provider Language
O-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl] O-ethyl S-propyl phosphorothioate English
Pyraclofos Usage And Synthesis
Uses Pyraclofos is used to control Lepidoptera, Coleoptera, mites and nematodes in fruit, vegetables, ornamentals and forestry. It has also been used in a human health application to control filarial worms.
Metabolic pathway Pyraclofos is apparently subjected in insects to a metabolic activation to yield a more active acetylcholinesterase inhibitor which is possibly a thiooxidized metabolite. The compound is very rapidly degraded in mammals to inactive metabolites via P-O-aryl, P-O-alkyl and P-S-alkyl cleavage which explains its favourable selective toxicity. In both mammals and plants the principal degradative route is via P-O-aryl cleavage to give 1-(4-chlorophenyl)-4-hydroxypyrazolwe hich is rapidly conjugated.
Degradation The DT50 for hydrolysis in water at pH 7 (25 °C) was 29 days (PM).