Hydrocortisone 21-hemisuccinate

Product Name: Hydrocortisone 21-hemisuccinate

Synonyms: cortisolsuccinate;hydrocortisone21-succinate;saxizon;(11-beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxypreg-4-ene-3,20-dione;17-dihydroxy-20-dion(11-beta)-preg-4-ene-21-(3-carboxy-1-oxopropoxy)-11;cortisol,21-(hydrogensuccinate);cortisol,hydrogensuccinate;11beta,17,21-Trihydroxypregn-4-ene-3,20-dione21-(hydrogensuccinate)

CAS: 2203-97-6

MF: C25H34O8

MW: 462.53

EINECS: 218-612-3

Product Categories: Steroid and Hormone;Steroids

Mol File: 2203-97-6.mol

Hydrocortisone 21-hemisuccinate Structure

Hydrocortisone 21-hemisuccinate Chemical Properties

Melting point 170～172℃

alpha [α]D20 +147～+153° (c=1, C2H5OH) (After Drying)

Boiling point 685.5±55.0 °C(Predicted)

density 1.33±0.1 g/cm3(Predicted)

storage temp. −20°C

solubility Practically insoluble in water, freely soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali carbonates and alkali hydroxides.

pka pKa 5.10/5.64(20% aq EtOH/50% aq EtOH) (Uncertain)

form neat

Safety Information

Safety Statements 22-24/25

WGK Germany 3

RTECS TU5010147

MSDS Information

Provider Language

SigmaAldrich English

Hydrocortisone 21-hemisuccinate Usage And Synthesis

Chemical Properties White or almost white, hygroscopic powder

Uses glucocorticoid

Definition ChEBI: A derivative of succinic acid in which one of the carboxy groups is esterified by the C-21 hydroxy group of cortisol (hydrocortisone).

Brand name A-Hydrocort (Abbott); A-Hydrocort (Hospira); Solu-Cortef (Pharmacia & Upjohn).

Hydrocortisone 21-hemisuccinate Preparation Products And Raw materials