O-Phospho-L-serine
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:1ton
- Time:2019-12-31
Product Details
- Product NameO-Phospho-L-serine
- CAS No. 407-41-0
- EINECS No.200-158-5
- MFC3H8NO6P
- MW185.07
- InChIKeyBZQFBWGGLXLEPQ-REOHCLBHSA-N
- AppearanceCrystalline PowderWhite
- Melting point 190 °C(lit.)
- storage temp. under inert gas
- Boiling point 475.4±55.0 °C(Predicted)
- density 1.809±0.06 g/cm3(Predicted)
- Water Solubility 28.34g/L at 20℃
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O-Phospho-L-serine Basic information
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Product Name:
Synonyms:
O-PHOSPHO-L-SERINE;SERINE(PO3H2)-OH;dexfosfoserine;L-(+)-serine 3-(dihydrogen phosphate);L-Phosphoserine Anhydrous;Phosphoserinebariumsalt;O-phosphoserine;Serine phosphate
CAS:
MF:
C3H8NO6P
MW:
185.07
EINECS:
206-986-0
Product Categories:
Mol File:
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O-Phospho-L-serine Chemical Properties
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Melting point
190 °C(lit.)
alpha
[α]D20 +14～+18°(c=5,dil.HCl)
Boiling point
475.4±55.0 °C(Predicted)
density
1.809±0.06 g/cm3(Predicted)
storage temp.
Store at 0°C
solubility
H2O: 50 mg/mL hot, clear, colorless to slightly yellow
pka
pK1:2.08;pK2:5.65;pK3:9.74 (25°C)
form
Crystalline Powder
color
White
Merck
14,7363
BRN
1726826
InChIKey
BZQFBWGGLXLEPQ-UWTATZPHSA-N
CAS DataBase Reference
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Safety Information
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O-Phospho-L-serine Usage And Synthesis
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Chemical Properties
White powder
Uses
roborant
Uses
L-O-Phosphoserine is the catalytic domain of human protein kinase C β II when complexed with a malemide inhibitor. It is also used in the purification of the Epstein-Barr virus nuclear antigen 2A.
Uses
O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.
Biological Activity
Group III metabotropic glutamate receptor agonist; analog of L-AP4 (L-(+)-2-Amino-4-phosphonobutyric acid ). Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
Purification Methods
Recrystallise the phospho-serine by dissolving 10g in H2O (150mL) at 25o, stirring for up to 20minutes. Undissolved material is filtered off (Büchner), and 95% EtOH (85mL) is added dropwise during 4minutes, and set aside at 25o for 3hours, then at 3o overnight. The crystals are washed with 95% EtOH (100mL), then dry Et2O (50mL), and dried in a vacuum (yield 6.5g). A further quantity (1.5g) can be obtained by keeping the mother liquors and washings at -10o for 1 week. The DL-isomer has m 167-170o(dec) after recrystallisation from H2O/EtOH or MeOH. [Neuhaus & Korkes Biochemical Preparations 6 75 1958, Neuhaus & Byrne J Biol Chem 234 113 1959, IR: F.lsch & Mellander Acta Chem Scand 11 1232 1957, Beilstein 4 IV 3120.]
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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