(-)PPP
| Price | USD1.00 |
| Packge | 1g |
- Min. Order:1g
- Supply Ability:200kg
- Time:2019-12-31
Product Details
- Product Name(-)PPP
- CAS No.477-47-4
- MFC22H22O8
- MW414.41
- Appearancepowderwhite
- storage temp. Sealed in dry,2-8°C
- density 1.370
- Melting point 225-227℃
- Boiling point 453.31°C (rough estimate)
Mary
▼
▲
Product Name:
Synonyms:
IGF-1R Inhibitor, PPP - CAS 477-47-4 - Calbiochem;AXL 1717;AXL1717;AXL-1717;(5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;Picropodophyllotoxin, >=98%;PICROPODOPHYLLIN;(-)PPP
CAS:
MF:
C22H22O8
MW:
414.40528
EINECS:
Product Categories:
Mol File:
▼
▲
(-)PPP Chemical Properties
▼
▲
Melting point
225-227℃
alpha
D20 +9.4° (c = 0.7 in chloroform)
Boiling point
453.31°C (rough estimate)
density
1.370
refractive index
1.4480 (estimate)
storage temp.
2-8°C
solubility
H2O: soluble
pka
13.26±0.40(Predicted)
form
powder
color
white
Sensitive
Light Sensitive
▼
▲
Safety Information
▼
▲
Hazard Codes
Risk Statements
Safety Statements
RIDADR
UN 3462 6.1/PG 2
WGK Germany
3
RTECS
LV2510000
HazardClass
6.1
Toxicity
LD50 intraperitoneal in mouse: 280mg/kg
▼
▲
Provider
Language
English
▼
▲
(-)PPP Usage And Synthesis
▼
▲
Uses
Insulin growth factor 1 receptor inhibitor, antineoplastic
Definition
ChEBI: An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.
Biological Activity
Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC 50 ~ 1 nM), increases the fraction of cells in the G 2 /M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC 50 = 0.05 - 15 μ M), and has anticancer and antineovascularization activity in vivo .
▼
▲
(-)PPP Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
INQUIRY