M344
| Price | USD1.00 |
| Packge | 1g |
- Min. Order:1g
- Supply Ability:200kg
- Time:2019-12-26
Product Details
- Product NameM344
- CAS No.51456-60-7
- MFC16H25N3O3
- MW307.39
- AppearanceWhite solidwhite to beige
- storage temp. 2-8°C
- Melting point 161℃
- density 1.137±0.06 g/cm3(Predicted)
Mary
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Product Name:
Synonyms:
4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, MS 344, D237, N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide;4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide;MS 344;4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide;M 344 (enzyme inhibitor);MS 344, D237;Histone Deacetylase Inhibitor III(M344);M344
CAS:
MF:
C16H25N3O3
MW:
307.39
EINECS:
Product Categories:
Mol File:
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M344 Chemical Properties
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Melting point
161℃
storage temp.
2-8°C
solubility
DMSO: soluble10mg/mL, clear
form
White solid
color
white to beige
Sensitive
Light Sensitive
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Safety Information
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WGK Germany
3
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M344 Usage And Synthesis
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Uses
Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs.
Uses
M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).
Biological Activity
Histone deacetylase inhibitor (IC 50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.
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M344 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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