TANDOSPIRONE
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:100kg
- Time:2019-12-26
Product Details
- Product NameTANDOSPIRONE
- CAS No.87760-53-0
- MFC21H29N5O2
- MW383.49
- AppearanceSolidWhite to Off-White
- storage temp. Store at +4°C
- Melting point 112-113.5°
- Boiling point 613.9±65.0 °C(Predicted)
- density 1.239±0.06 g/cm3(Predicted)
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Product Name:
Synonyms:
TANDOSPIRONE;4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aa,4b,7b,7aa)-;4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel- (9CI);(3αα，4β，7β，7αα)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4，7-methano-1H-isoindole-1，3(2H)-dione;Sediel;3a,4,7,7a-Hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-methano-1H-isoindole-1,3(2H)-dione;Tandospirone [inn:ban];(3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dionehydrochloride
CAS:
MF:
C21H29N5O2
MW:
383.49
EINECS:
Product Categories:
Mol File:
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TANDOSPIRONE Chemical Properties
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Melting point
112-113.5°
Boiling point
613.9±65.0 °C(Predicted)
density
1.239±0.06 g/cm3(Predicted)
storage temp.
Store at +4°C
solubility
DMSO: soluble38mg/mL
pka
7.71±0.10(Predicted)
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Safety Information
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TANDOSPIRONE Usage And Synthesis
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Description
Sediel was launched in Japan as an anxiolytic agent and is a member of the azapirone family. Ready access to the compound is attained from the ex0 Diels- Alder adduct of maleic anhydride and cyclopentadiene in a four step convergent approach. Biochemically, it is a partial agonist of the post-synaptic 5-HT1a receptor. This metabotropic receptor is coupled to the G proteins and suppresses adenylate cyclase and phosphatidylinositol metabolism systems. It has low affinity for dopamine D2, 5-HT2 and α1-adreneric receptors and no affinity for benzodiazepine, GABA or 5-HT1b binding sites. The primary metabolic product is two orders of magnitude less active. Tandospirone is as effective as benzodiazepines in anxiolytic activity but does not have the side-effects (low abuse potential, weak sedative, no anticonvulsant activity).
Originator
Sumitomo (Japan)
Uses
Tandospirone is a 5HT1A receptor partial agonist. Studies indicate that tandospirone significantly reduces haloperidol-induced bradykinesia in a dose dependent manner. The potency of Tandospirone is equal to that of buspirone and approximate one-half that of diazepam. The potency of Tandospirone at dopamine antagonistic action is less than 1/4 that of buspirone.
Brand name
Sediel
Biological Activity
5-HT 1A receptor partial agonist (K i = 27 nM) that displays selectivity over 5-HT 2 , 5-HT 1C , α 1 , α 2 , D 1 and D 2 receptors (K i values ranging from 1300-41000 nM). Inactive at 5-HT uptake sites, 5-HT 1B , β -adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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