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HomecompanyFactory high quality and low price Radotinib
Radotinib
Radotinib
Radotinib
Radotinib
Radotinib
Radotinib

Factory high quality and low price Radotinib

Price USD1.00
Packge 1KG
  • Min. Order:1KG
  • Supply Ability:g/kg/Ton
  • Time:2019-12-26

Product Details

  • Product NameRadotinib
  • CAS No.926037-48-1
  • MFC27H21F3N8O
  • MW530.5
  • AppearancesolidLight yellow to yellow
  • density 1.40±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C

Heidi 0776

Email:heidi@coreychem.com

Radotinib Basic information
Product Name:
Synonyms:
IY5511;Radotinib;Radotinib HCl;Supect;Radotinib(IY-5511);4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-(4-(pyrazin-2-yl)pyrimidin-2-ylamino)benzamide
MF:
C27H21F3N8O
MW:
530.5038496
EINECS:
 
Product Categories:
Mol File:
Radotinib Structure
 
Radotinib Chemical Properties
density 
1.40±0.1 g/cm3(Predicted)
pka
12.94±0.70(Predicted)
 
Safety Information
MSDS Information
 
 
Radotinib Usage And Synthesis
Description
Radotinib, an inhibitor of Bcr–Abl tyrosine kinase,was approved in January 2012 in Korea as a second-line treatment for chronic myeloid leukemia (CML). Radotinib is a TKI with a similar structure to the second-generation TKI, nilotinib, in which a pyridyl group has been replaced with a pyrazinemoiety. The in vitro activity of radotinib against a variety of tumor cell lines is disclosed in an issued patent. Radotinib was significantly more potent than imatinib in all of the cell lines tested. The synthesis of radotinib via amide coupling is described in the patent literature.
Originator
Il-Yang (Korea)
Indications
Radotinib (Supect(R), Il-Yang Pharmaceutical) is a Bcr–Abl inhibitor that was approved in South Korea in 2012 for the treatment of imatinib-resistant CML. Radotinib, which has a terminal 4-(pyridine-2-yl) pyrimidine moiety, was developed based on the previously approved Bcr–Abl inhibitors nilotinib. Radotinib has equivalent efficacy with that of other second-generation Bcr–Abl inhibitors and is well tolerated in chronic-phase CML patients. The lower cost of radotinib compared with other FDA-approved Bcr–Abl inhibitors makes it an attractive alternative for the treatment of CML in developing nations.
Brand name
Supect

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;
  • Since:2014-12-17
  • Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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