Factory high quality and low price Bupropion
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:g/kg/Ton
- Time:2019-12-26
Product Details
- Product NameBupropion
- CAS No.34841-39-9
- EINECS No.218-319-0
- MFC13H18ClNO
- MW239.74
Heidi 0755
Email:heidi@coreychem.com
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Bupropion Basic information
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Product Name:
Synonyms:
1-(3-chlorophenyl)-2-(tert-butylamino)propan-1-one;2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one;WELLBUTRIN;Bupropion;Bupivacaine I
CAS:
MF:
C13H18ClNO
MW:
239.74
EINECS:
Product Categories:
Mol File:
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Bupropion Chemical Properties
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Safety Information
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Bupropion Usage And Synthesis
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Uses
enteric coating
Enzyme inhibitor
This β-ketoamphetamine-type antidepressant and smoking cessation aid (FW = 239.74 g/mol; CAS 34841-39-9), also known as Wellbutrin?, Zyban?, and (±)-2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one, is said to be a norepinephrine and dopamine reuptake inhibitor, although its weak effect on dopamine levels calls into question the latter action. Bupropion also acts noncompetitively as a neuronal acetylcholine receptor antagonist. Unlike many antidepressants, however, bupropion shows no serotonergic activity. It also lacks typical antidepressant side effects, e.g., sexual dysfunction, weight gain, and sedation. Pharmacokinetics: Upon oral administration, bupropion is rapidly absorbed with first-order kinetics and subsequently eliminated via biphasic kinetics, with a redistribution t1/2 of ~1 hour and an elimination t1/2 of 11-14 hours. Widely distributed throughout the body, bupropion is extensively metabolized, both oxidatively and reductively, to form as many as six metabolites, of which some are pharmacologically active. While bupropion does not inhibit monoamine oxidase, it exerts no effect on serotonin uptake. It minimally alters the reuptake of norepinephrine at presynaptic sites. Importantly, bupropion does not act on postsynaptic b-adrenergic down-regulation or presynaptic dopamine uptake. Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics. Key Pharmacokinetic Parameters: See Appendix II in Goodman & Gilman’s THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, 12th Edition (Brunton, Chabner & Knollmann, eds.) McGraw-Hill Medical, New York.
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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