Factory high quality and low price LEPTOMYCIN B FROM STREPTOMYCES SPrimidine-2,4- diamine
| Price | USD1.00 |
| Packge | 1g |
- Min. Order:1g
- Supply Ability:g/kg/Ton
- Time:2019-12-26
Product Details
- Product NameLEPTOMYCIN B FROM STREPTOMYCES SP
- CAS No.87081-35-4
- EINECS No.617-954-4
- MFC33H48O6
- MW540.73
- AppearanceLiquidWhite to off-white
- storage temp. −20°C
- Melting point 41-44°, with prior softening (Hokanson)
- Boiling point 725.8±60.0 °C(Predicted)
- density 1.072±0.06 g/cm3(Predicted)
Heidi 0703
Email:heidi@coreychem.com
▼
▲
LEPTOMYCIN B FROM STREPTOMYCES SP Basic information
▼
▲
Product Name:
Synonyms:
InSolution Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem;LEPTOMYCIN B FROM STREPTOMYCES SP;Leptomycin B (CI 940;2,10,12,16,18-nonadecapentanoicacid,19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2;7,9,11,15-hexamethyl-8-oxo--yl)-17-ethyl-6-hydroxy-5;antibioticci940;antibioticcl1957a;CI-940, Elactocin, PD 114720, ATS 1287B, Mantuamycin, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-Nonadecapentaenoic acid
CAS:
MF:
C33H48O6
MW:
540.736
EINECS:
617-954-4
Product Categories:
Mol File:
▼
▲
LEPTOMYCIN B FROM STREPTOMYCES SP Chemical Properties
▼
▲
Melting point
41-44°, with prior softening (Hokanson)
alpha
D -24.5° (c = 0.70 in MeOH); D23 -157 ° (c = 0.7% in chloroform)
Fp
11°(52°F)
storage temp.
−20°C
form
Liquid
▼
▲
Safety Information
▼
▲
Hazard Codes
Risk Statements
Safety Statements
RIDADR
UN 1230 3/PG 2
WGK Germany
3
HazardClass
3
HS Code
29419090
▼
▲
LEPTOMYCIN B FROM STREPTOMYCES SP Usage And Synthesis
▼
▲
Uses
Leptomycin B is the dominant and most studied member of the leptomycin class, isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1, a protein in the nuclear export sequence (NES). Proteins affected include c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits export of many RNAs, e.g. COX-2 and c-FOS mRNA. Leptomycin B also shows antifungal and antibacterial and potent antitumour activities.
Uses
Leptomycin B is the dominant and most studied member of the leptomycin class, isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1, a protein in the nuclear export sequence (NES). Proteins affected include c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits export of many RNAs, e.g. COX-2 and c-FOS mRNA. Leptomycin B also shows antifungal, antibacterial and potent antitumor activities.
Uses
Biological tool for studying nuclear localization and protein trafficking in eukaryotic cells.
Definition
ChEBI: A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17.
Biological Activity
Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo .
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
INQUIRY