Factory high quality and low price CERULENIN
| Price | USD1.00 |
| Packge | 1g |
- Min. Order:1g
- Supply Ability:g/kg/Ton
- Time:2019-12-26
Product Details
- Product NameCERULENIN
- CAS No.17397-89-6
- EINECS No.241-424-8
- MFC12H17NO3
- MW223.27
- AppearanceWhite to off-white solidOff-white
- storage temp. −20°C
- Melting point 93.5℃
- Boiling point bp 120° (10-8 mm)
- density 1.1223 (rough estimate)
Heidi 0671
Email:heidi@coreychem.com
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CERULENIN Basic information
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Product Name:
Synonyms:
Aids000236;Aids-000236;Crl;Nsc116069;Cerulenin,(2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide;(2r,3s)-2,3-epoxy-4-oxo-7e,10e-dodecadienamide;(2s)(3r)-2,3-epoxy-4-oxo-7,10-dodecadienoylamide;Helicocerin, NSC 116069, 2,3-Epoxy-4-oxo-7,10-dodecadienaMide
CAS:
MF:
C12H17NO3
MW:
223.27
EINECS:
241-424-8
Product Categories:
Mol File:
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CERULENIN Chemical Properties
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Melting point
93.5℃
alpha
D16 +63° (c = 2 in methanol)
Boiling point
bp 120° (10-8 mm)
density
1.1223 (rough estimate)
refractive index
1.5300 (estimate)
storage temp.
−20°C
solubility
acetone: 20 mg/mL, clear, colorless to yellow
form
White to off-white solid
pka
15.19±0.40(Predicted)
Merck
13,2014
BRN
4140423
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Safety Information
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Provider
Language
English
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CERULENIN Usage And Synthesis
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Chemical Properties
White powder
Uses
Cerulenin is an epoxy fatty acid amide isolated from the fungus Cephalosporium caerulens and identified as an antifungal in the 1960s. Over the past 40 years, cerulenin has found broad application in lipid biochemistry as an inhibitor fatty acid and sterol biosynthesis. Cerulenin binds to β-keto-acyl-ACP synthase blocking the interaction of malonyl CoA. Cerulenin also an inhibits bacterial fatty acid synthesis, acting on the FabH, FabB and FabF condensation enzymes. Cerulenin stimulates fatty acid oxidation and inhibits HMG-CoA synthetase activity.
Uses
Cerulenin is an epoxy fatty acid amide isolated from the fungus Cephalosporium caerulens identified as an antifungal in the 1960s. Over the past 40 years, cerulenin has found broad application in lipid biochemistry as an inhibitor fatty acid and sterol biosynthesis. Cerulenin binds to β-keto-acyl-ACP synthase blocking the interaction of malonyl CoA. Cerulenin also an inhibits bacterial fatty acid synthesis, acting on the FabH, FabB and FabF condensation enzymes. Cerulenin stimulates fatty acid oxidation and inhibits HMG-CoA synthetase activity.
Definition
ChEBI: An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.
Purification Methods
It forms white needles from *C6H6. It has also been purified by repeated chromatography through Florisil and silica gel. It is soluble in EtOH, MeOH, *C6H6, slightly soluble in H2O and pet ether. The dl-form has m 40-42o (from *C6H6/hexane), and the 2R,3S-tetrahydrocerulenin has m 86-87o, [] 20 +44.4 (c 0.25, MeOH after 24hours). [Ohrui & Emato Tetrahedron Lett 2095 1978, Sneda et al. Tetrahedron Lett 2039 1979, Broeckman & Thomas J Am Chem Soc 99 2805 1977, Jakubowski et al. J Org Chem 47 1221 1982, Beilstein 18/2 V 201.]
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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