Factory high quality and low price DELAVIRDINE, MESYLATE
| Price | USD1.00 |
| Packge | 1g |
- Min. Order:1g
- Supply Ability:g/kg/Ton
- Time:2019-12-26
Product Details
- Product NameDELAVIRDINE, MESYLATE
- CAS No.147221-93-0
- MFC23H32N6O6S2
- MW552.67
- Appearancepowderwhite to tan
- Melting point 118-120°C
- storage temp. Inert atmosphere,Room Temperature
Heidi 0637
Email:heidi@coreychem.com
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DELAVIRDINE, MESYLATE Basic information
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Product Name:
Synonyms:
1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate;C08087;Delavirdine mesilate;MethanesulfonaMide, N-[2-[[4-[3-[(1-Methylethyl)aMino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-, Methanesulfonate;N-[2-[[4-[3-[(1-Methylethyl)aMino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]MethanesulfonaMide Methanesulfonate;Delavirdine methane sulfonate;N-[2-[[4-[3-[(1-Methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]methanesulfonamide mesylate;U-90152S
CAS:
MF:
C23H32N6O6S2
MW:
552.67
EINECS:
Product Categories:
Mol File:
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DELAVIRDINE, MESYLATE Chemical Properties
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Melting point
118-120°C
storage temp.
-20°C Freezer
solubility
DMSO: >5mg/mL
form
powder
color
white to tan
CAS DataBase Reference
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Safety Information
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WGK Germany
3
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DELAVIRDINE, MESYLATE Usage And Synthesis
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Description
Rescriptor was launched in the US for HIV positive individuals. It can be prepared in seven steps from 2-chloro-3-nitropyridine and piperazine. Rescriptor is a member of the bis(heteroaryl)piperazine (BHAP) class of non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs) of which it is a second generation drug. It acts exclusively as an allosteric mixed inhibitor of both RNA- and DNA-directed polymerase domains of RT and has a much higher binding affintiy for the enzymesubstrate complex than for the free enzyme. Rescriptor does not inhibit RNase H activity of RT. It prevented the spread of HIV significantly longer than AZT. Development of resistance to Rescriptor can occur, however the mutated strain becomes more vulnerable to other members of the NNRTIs. It is metabolized in the liver by CYP3A.
Chemical Properties
Light Brown Solid
Originator
Pharmacia ＆ Upjohn (US)
Uses
A bisheteroarylpiperazine (BHAP) reverse transcriptase inhibitor
Definition
ChEBI: The monomethanesulfonic acid salt of delavirdine, a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.
Brand name
Rescriptor (Agouron).
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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