CFTRinh-172
| Price | USD1.00 |
| Packge | 1g |
- Min. Order:1g
- Supply Ability:20kg
- Time:2019-12-24
Product Details
- Product NameCFTRinh-172
- CAS No.307510-92-5
- MFC18H10F3NO3S2
- MW409.4
- AppearanceYellow solidyellow
- storage temp. 2-8°C
- Melting point 181-183 °C
- Boiling point 555.7±60.0 °C(Predicted)
- density 1.61±0.1 g/cm3(Predicted)
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Product Name:
Synonyms:
InSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem;4-[4-OXO-2-THIOXO-3-(3TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-5-YLIDENEMETHYL]-BENZOIC ACID (FOR R&D ONLY);4-[[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid;4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoicacid;CFTRinh 172 (CFTR Inhibitor-172);Benzoic acid, 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-;CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem;3-[(3-Trifluoromethyl)Phenyl]-5-[(4-Carboxyphenyl)Methylene]-2-Thioxo-4-Thiazolidinone 4-[(Z)-[4-Oxo-2-Sulfanylidene-3-[3-(Trifluoromethyl)Phenyl]-1,3-Thiazolidin-5-Ylidene]Methyl]Benzoic Acid
CAS:
MF:
C18H10F3NO3S2
MW:
409.4
EINECS:
Product Categories:
Mol File:
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CFTRinh-172 Chemical Properties
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Melting point
181-183 °C
Boiling point
555.7±60.0 °C(Predicted)
density
1.61±0.1 g/cm3(Predicted)
storage temp.
Store at +4°C
solubility
DMSO: ≥10mg/mL
pka
3.88±0.10(Predicted)
form
Yellow solid
color
yellow
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Safety Information
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Hazard Codes
Risk Statements
Safety Statements
RIDADR
UN 3077 9 / PGIII
WGK Germany
3
HazardClass
IRRITANT
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CFTRinh-172 Usage And Synthesis
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Uses
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR Inhibitor-172 is a thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner. It appears to directly modulate the gating of chloride at the channel and does not prevent elevation of cAMP or inhibit other pumps or channels. In mice, CFTR inhibitor-172 prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection. It slows cyst growth in animal models of polycystic kidney disease. As CFTR also modulates glutathione (GSH) efflux, CFTR inhibitor-172 can affect intracellular GSH concentration and reactive oxygen species balance.
Definition
ChEBI: A thiazolidinone that is 2-thioxo-4-thiazolidinone which is substituted at position 3 by a (m--trifluoromethyl)phenyl group and at position 5 by a p-carboxybenzylidene group. It is an inhibitor of cystic fibrosis transmembrane con uctance regulator, a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene.
Biological Activity
Voltage-independent, selective CFTR chloride channel blocker (K i = 300 nM) that alters channel gating. Blocks intestinal fluid secretion induced by cholera toxin and Escherichia coli and suppresses cyst growth in animal models of polycystic kidney disease. Orally active. Inhibits mitochondrial respiration and increases reactive oxygen species (ROS) production independently of CFTR in several cell lines.
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CFTRinh-172 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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