ANA12
| Price | USD1.00 |
| Packge | 1g |
- Min. Order:1g
- Supply Ability:20kg
- Time:2019-12-24
Product Details
- Product Name ANA12
- CAS No.219766-25-3
- EINECS No.803-090-7
- MFC22H21N3O3S
- MW407.49
- Appearancepowderwhite to beige
- storage temp. 2-8°C
- density 1.36±0.1 g/cm3(Predicted)
- Boiling point 639.2±55.0 °C(Predicted)
Mary
▼
▲
Product Name:
Synonyms:
ANA12;N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide;N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide
CAS:
MF:
C22H21N3O3S
MW:
407.48544
EINECS:
803-090-7
Product Categories:
Mol File:
▼
▲
ANA12 Chemical Properties
▼
▲
storage temp.
2-8°C
solubility
DMSO: ≥5mg/mL at 60°C
form
powder
color
white to beige
▼
▲
ANA12 Usage And Synthesis
▼
▲
ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively.
ANA-12 binds directly and selectively to TrkB and inhibits processes downstream of TrkB without altering TrkA and TrkC functions. In nnr5 PC12-TrkB cells, ANA-12 prevents brain-derived neurotrophic factor (BDNF)-induced neurite outgrowth at concentrations as low as 10 nM. In DRG neurons, ANA-12 eliminates the effect of BDNF on increasing inward current.
In adult C57BL6/129SveV F1s mice, ANA-12 (0.5 mg/kg, i.p.) decreases TrKB activity in the brain and reduces the anxiety- and depression-related behaviors without affecting the neuron survival. In male C57BL/6 mice, ANA-12 (0.5 mg/kg, i.p.) shows antidepressant-like effects on lipopolysaccharide-induced depression-like behavior. In male Sprague-Dawley rats, ANA-12 (3 μg/dose) blocks the effect of medial nucleus tractus solitarius (mNTS) BDNF on reducing food intake. In male wild-type mice, ANA-12 reverses ethanol intake and induces D3 receptor downregulation, but is ineffective in D3R-/- mice. In male CocSired rats, ANA-12 (0.5 mg/kg, i.p.) reverses the diminished self-administration of cocaine.
▼
▲
ANA12 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
INQUIRY