Necrostatin-1
Price | USD5.00 |
Packge | 5KG |
- Min. Order:1KG
- Supply Ability:1ton
- Time:2019-09-04
Product Details
- Product NameNecrostatin-1
- CAS No.4311-88-0
- EINECS No.200-256-5
- MFC13H13N3OS
- MW259.33
- AppearancesolidPale yellow
- storage temp. -20°C
- density 1.40±0.1 g/cm3 (20 ºC 760 Torr)
- Melting point 151℃
- Boiling point 441.9±37.0 °C(Predicted)
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Necrostatin-1 Basic information
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Product Name:
Synonyms:
Necrostatin-1 - CAS 4311-88-0 - Calbiochem;IFLAB-BB F0911-6127;5-(1H-INDOL-3-YLMETHYL)-3-METHYL-2-THIOXO-4-IMIDAZOLIDINONE;5-(INDOL-3-YLMETHYL)-3-METHYL-2-THIO-HYDANTOIN;NECROSTATIN-1;MTH-DL-TRYPTOPHAN;MTH-DL-Tryptophan Methylthiohydantoin-DL-tryptophan;5-(1H-Indole-3ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
CAS:
MF:
C13H13N3OS
MW:
259.33
EINECS:
Product Categories:
Mol File:
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Necrostatin-1 Chemical Properties
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Melting point
151℃
density
1.40±0.1 g/cm3 (20 ºC 760 Torr)
Fp
93.3℃
storage temp.
−20°C
solubility
DMSO: >10 mg/mL
form
solid
Sensitive
Light Sensitive
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Safety Information
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English
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Necrostatin-1 Usage And Synthesis
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Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells.
A powerful tool for characterizing the role of necroptosis with characterized primary target.
Necrostatin-1 (1-100 μM) inhibits the autophosphorylation of overexpressed and endogenous RIP1.It is found RIP1 is the primary cellular target responsible for the antinecroptosis activity of Necrostatin-1. Necrostatin-1 efficiently suppresses necroptotic cell death triggered by an array of stimuli in a variety of cell types. Necrostatin-1, previously identified as small-molecule inhibitor of necroptosis, inhibits RIP kinase-induced necroptosis and inhibits TNF-α-induced necroptosis in jurkat cells with EC50 of 490 nM.
Uses
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
Uses
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.
Biological Activity
ATP-competitive death domain receptor-associated adaptor kinase (RIP1) allosteric inhibitor (EC 50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC 50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.
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Necrostatin-1 Preparation Products And Raw materials
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates:
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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