Tacedinaline

Tacedinaline Basic information

Product Name:

Synonyms:

Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-;acetyldinaline;Tacedinaline;CI 994;N-Acetyldinaline;4-AcetaMido-N-(2-aMinophenyl)benzaMide;4-Acetylamino-N-(2'-aminophenyl)benzamide;Cl-994(Tacedinalin,N-Acetyldinalin)

CAS:

MF:

C15H15N3O2

MW:

269.3

EINECS:

 

Product Categories:

Apoptosis Inducers;Inhibitor;-;Inhibitors

Mol File:

 

Tacedinaline Chemical Properties

RTECS 

CU8702023

storage temp. 

Store at +4°C

solubility 

Soluble in DMSO

form 

powder

color 

off-white

Sensitive 

Air Sensitive

 

Safety Information

Hazard Codes 

Risk Statements 

Safety Statements 

WGK Germany 

3

MSDS Information

 

Tacedinaline Usage And Synthesis

Uses

Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tum or cells. Studies show Tacedinaline to be effective against acute myeloid leukemia in vitro and in vivo when used in combination with conventional anti-cancer agents.

Definition

ChEBI: A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Al o used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.

Biological Activity

Orally active histone deacetylase (HDAC) inhibitor (K i values are 0.41, 0.75, >100 and >100 μ M for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G 1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo .

 

Tacedinaline Preparation Products And Raw materials