PeraMpanel
| Price | USD7.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:JD 474
- Time:2019-09-02
Product Details
- Product Name PeraMpanel
- CAS No. 380917-97-5
- EINECS No.691-969-4
- MFC23H15N3O
- MW349.38
- AppearancePowder
- Boiling point 619.1±55.0 °C(Predicted)
- density 1.31±0.1 g/cm3(Predicted)
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Product Name:
Synonyms:
PeraMpanel;E 2007;ER 155055-90;PeraMpanel-D5;PeraMpanel-13C6;3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one;3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one;2-(2-oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile
CAS:
MF:
C23H15N3O
MW:
349.3847
EINECS:
691-969-4
Product Categories:
Mol File:
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PeraMpanel Chemical Properties
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Safety Information
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PeraMpanel Usage And Synthesis
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Perampanel (licensed in 2012) is a third- generation AED known with the proprietary brand name of Fycompa® (Eisai, Hatfield) in the UK and Banzel® (Eisai, Hatfield) in the USA.
Epilepsy: Adjunctive treatment of focal seizures with or without secondary generalization and primary generalized tonic- clonic seizures.
Epilepsy— adjunctive therapy: 2 mg nocte for at least 14 days, then increased by 2 mg every 14 or more days; usual maintenance 4– 8 mg nocte (max. 12 mg nocte).
With AEDs
With other drugs
With alcohol/food
- Some AEDs known as CYP450 3A enzyme inducers (carbamazepine, oxcarbazepine, phenytoin) have been shown to increase perampanel clearance and consequently to decrease plasma concentrations of perampanel. Carbamazepine, a known potent enzyme inducer, reduced perampanel levels by two- thirds in a study performed on healthy subjects
- In the epilepsy population pharmacokinetic analysis, perampanel was found to decrease the clearance of oxcarbazepine by 26%. Oxcarbazepine is rapidly metabolized by cytosolic reductase enzyme to the active metabolite, monohydroxycarbazepine. The effect of perampanel on monohydroxycarbazepine concentrations is not known.
With other drugs
- Strong inducers of cytochrome P450, such as rifampicin and St John’s Wort (Hypericum perforatum), are expected to decrease perampanel concentrations.
- In healthy subjects, the CYP3A4 inhibitor ketoconazole increases perampanel exposure.
- Perampanel can make certain hormonal contraceptives such as levonorgestrel less effective.
- Decrease in exposure of midazolam may be caused by perampanel.
With alcohol/food
- Drinking alcohol while taking perampanel can affect a patients’ alertness and ability to drive or use tools or machines. It can also aggravate irritability, confusion, and depression.
- There are no specific foods that must be excluded from diet when taking perampanel.
Hepatic impairment
Renal impairment
Avoid in moderate or severe impairment.
Pregnancy
- Increase at intervals of at least 2 weeks, up to a maximum of 8 mg daily, in mild- to- moderate impairment.
- Avoid in severe impairment.
Renal impairment
Avoid in moderate or severe impairment.
Pregnancy
- There are limited amount of data available on the use of perampanel in pregnant women and the potential risk for humans is unknown.
- Perampanel is not recommended in pregnancy and female patients must use a reliable method of contraception to avoid becoming pregnant while being treated with perampanel (this should be continued for 1 month after stopping treatment).
- As perampanel can make certain hormonal contraceptives such as levonorgestrel less effective, other forms of safe and effective contraception (such as a condom or coil) should be used when taking perampanel (this should be continued for 1 month after stopping treatment).
- Perampanel has been found to be present in milk in animal studies and it is recommended that breastfeeding should be avoided.
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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