Temoporfin
| Price | USD3.00 |
| Packge | 3ASSAYS |
- Min. Order:1KG
- Supply Ability:100kg
- Time:2019-07-10
Product Details
- Product NameTemoporfin
- CAS No.122341-38-2
- EINECS No.624-374-5
- MFC44H32N4O4
- MW680.75
- AppearanceSolidPurple
- Melting point >250 °C
- density 1.386±0.06 g/cm3(Predicted)
- storage temp. Amber Vial, -20°C Freezer, Under inert atmosphere
| Temoporfin Basic information |
| Product Name: | Temoporfin |
| Synonyms: | temoporfin;8-dihydroporphyrin-5;5,10,15,20-tetra(m-hydroxyphenyl)chlorin;3,3',3'',3'''-(7,8-dihydroporphyrin-5,10,15,20-tetrayl)tetraphenol;TeMoporfin(KW-2345,EF9);EF 9;Foscan;Fosgel |
| CAS: | 122341-38-2 |
| MF: | C44H32N4O4 |
| MW: | 680.761 |
| EINECS: | 624-374-5 |
| Product Categories: | |
| Mol File: | 122341-38-2.mol |
 |
|
| Temoporfin Chemical Properties |
| Safety Information |
| Temoporfin Usage And Synthesis |
| Description | Temoporphin, a second generation photosensitizer, was launched in UK for the photodynamic therapy (PDT) of advanced head and neck cancers. This porphyrin derivative can be synthesized from pyrrole and 3-hydroxybenzaldehyde. The pharmacological activity is initiated, 4 days after intravenous injection, by laser-light photoactivation of temoporphin, that has selectively accumulated in cancer tissues. The resulting generation of highly reactive oxygen species leads to malignant cells death thereby inducing tumor necrosis up to a depth of 15 mm. An advantage of temoporphin over other photosensitizing agents is its extreme sensitivity to wavelengths of light that penetrate tissues, resulting in lower light/dose and irradiation time. PDT with intravenous temoporphin has produced relatively high complete and partial response rates in head and neck cancers, with higher response rates generally observed with higher light dose. Temoporphin is well-tolerated and does not preclude surgery/radiotherapy as a later option. Adverse effects were photosensitivity and pain at the injection site. |
| Originator | Quanta Nova (UK) |
| Uses | Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells. When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor. Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest. |
| Brand name | Foscan |
| Temoporfin Preparation Products And Raw materials |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY