Costunolide
| Price | USD1.00 |
| Packge | 1kg |
- Min. Order:1g
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NameCostunolide
- CAS No.553-21-9
- MFC15H20O2
- MW232.32
- Appearancepowderwhite to beige
- storage temp. -20°C
- Melting point 106-107 °C
- Boiling point 385.4±42.0 °C(Predicted)
- density 1.03±0.1 g/cm3(Predicted)
| Costunolide Basic information |
| Product Name: | Costunolide |
| Synonyms: | Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3- methylene-, [3aS-(3aR*,6E,10E,11aS*)]-;CUSTUNOLIDE;(3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one;COSTUNDIDE;Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a-;hexahydro-6,10-dimethyl-3-methylene-,(3aS,6E,10E,11aR)-;(3aS,6E,10E)-3aβ,4,5,8,9,11aβ-Hexahydro-6,10-dimethyl-3-methylenecyclodeca[b]furan-2(3H)-one;(3aS,6E,10E)-3-Methylene-6,10-dimethyl-2,3,3aβ,4,5,8,9,11aα-octahydrocyclodeca[b]furan-2-one |
| CAS: | 553-21-9 |
| MF: | C15H20O2 |
| MW: | 232.32 |
| EINECS: | |
| Product Categories: | Miscellaneous Natural Products;chiral;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Sesquiterpenoids |
| Mol File: | 553-21-9.mol |
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| Costunolide Chemical Properties |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble10mg/mL (clear solution) |
| color | white to beige |
| InChIKey | HRYLQFBHBWLLLL-GRFSRWIASA-N |
| CAS DataBase Reference | 553-21-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Germacra-1(10),4,11(13)-trien-12-oic acid, 6«alpha»-hydroxy-, «gamma»-lactone, (e,e)-(553-21-9) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-24/25 |
| HS Code | 29322090 |
| Costunolide Usage And Synthesis |
| Chemical Properties | White powder |
| Uses | A sequiterpene lactone that inhibits telomerase |
| Definition | ChEBI: A germacranolide with anthelminthic, antiparasitic and antiviral activities. |
| Biological Activity | Inhibitor of human telomerase activity (IC 50 = 65 μ M in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1 β and disrupts NF- κ B activation. Displays anti-inflammatory, antifungal and antiviral properties. |
| Contact allergens | This germacranolide sesquiterpene lactone is extracted from costus oil. With alantolactone and dehydrocostunolide, it is a component of lactone mix used to elicit reactions in patients sensitive to Asteraceae-Compositae. An erythema-multiform-like occupational contact dermatitis case occurred in a chemical student after an accidental exposure to costus oil. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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