Perifosine (KRX-0401)
| Price | USD2.00 |
| Packge | 1kg |
- Min. Order:1kg
- Supply Ability:100kg
- Time:2019-07-06
Product Details
- Product NamePerifosine (KRX-0401)
- CAS No.157716-52-4
- EINECS No.690-653-3
- MFC25H52NO4P
- MW461.663
- Appearancepowderwhite to beige
- storage temp. -20°C
- Melting point 271-272° (dec)
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| erifosine (KRX-0401) Basic information |
| Product Name: | Perifosine (KRX-0401) |
| Synonyms: | Perifosine;(1,1-Dimethylpiperidin-1-ium-4-yl) octadecyl phosphate;4-((Hydroxy(octadecyloxy)phosphinyl)oxy)-1,1-dimethylpiperidinium inner salt;Perifosine,D 21266;4-[[Hydroxy(octadecycloxy)phosphinyl]oxy]-1,1-diMethylpiperidiniuM inner salt;D-21266 octadecyl-(N,N-diMethyl-piperidino-4-yl)-phosphate;NSC 639966;Perifosine(KRX-0401) |
| CAS: | 157716-52-4 |
| MF: | C25H52NO4P |
| MW: | 461.663 |
| EINECS: | 1592732-453-0 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Antineoplastic;PI3K/Akt/mTOR;Inhibitors;Akt;mTOR;PI3K |
| Mol File: | 157716-52-4.mol |
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| Perifosine (KRX-0401) Chemical Properties |
| Melting point | 271-272° (dec) |
| storage temp. | ?20°C |
| solubility | H2O: soluble10mg/mL, clear |
| color | white to beige |
| InChIKey | SZFPYBIJACMNJV-UHFFFAOYSA-N |
| Safety Information |
| Perifosine (KRX-0401) Usage And Synthesis |
| Description | Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3. |
| In vitro | Perifosine develops anti-proliferative properties with IC50 of 0.6-8.9 μM in immortalized keratinocytes (HaCaT), and head and neck squamous carcinoma cells. Perifosine strongly reduces phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk) 1/2, induces cell cycle arrest in G1 and G2, and causes dose-dependent growth inhibition of mouse glial progenitors. Perifosine (10 μM) completely inhibits the phosphorylation of Akt in MM.1S cells. A recent study demonstrates Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. |
| In vivo | Perifosine combining with temozolomide reduces tumor proliferation (a PDGF-driven gliomagenesis) in vivo. The results indicate that Perifosine is an effective drug in gliomas in which Akt and Ras-Erk 1/2 pathways are frequently activated, and may be new candidate for glima treatment in the clinic. Both oral daily and weekly administration of Perifosine significantly reduce human MM tumor growth and increase survival, compared with control animals treated with PBS vehicle only. Perifosine induces thrombocytosis and leukocytosis and increases myelopoiesis in murine marrow and spleen, whereas it causes apoptosis in myeloma xenografts. |
| Uses | Antineoplastic. |
| Uses | It acts as an Akt inhibitor and a PI3K inhibitor, and is a drug candidate being developed for a variety of cancer indications. |
| Uses | An alkylphospholipid which inhibits Akt activation and the anti-apoptotic MAPK pathway. |
| Definition | ChEBI: A phospholipid consisting of 1,1-dimethylpiperidinium-4-yl hydrogen phosphate in which the hydrogen is replaced by a stearyl (octadecyl) group. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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