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Coumarin
Coumarin

Coumarin

Price USD1.00
Packge 1kg
  • Min. Order:1g
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameCoumarin
  • CAS No.91-64-5
  • EINECS No.202-086-7
  • MFC9H6O2
  • MW146.14
  • InChIKeyZYGHJZDHTFUPRJ-UHFFFAOYSA-N
  • AppearanceCrystals or Crystalline PowderWhite
  • density 0.935
  • Water Solubility 1.7 g/L (20 ºC)
  • Melting point 68-73 °C (lit.)
  • Boiling point 298 °C (lit.)
  • storage temp. Store below +30°C.
Coumarin Basic information
Brief Introduction Chemical Properties Uses
Product Name: Coumarin
Synonyms: TIMTEC-BB SBB000094;O-HYDROXYCINNAMIC ACID LACTONE;TONKA BEAN CAMPHOR;5,6-BENZO-2-PYRONE;AKOS 212-75;2H-1-BENZOPYRAN-2-ONE;2H-1-BENZOPYAN-2-ONE;1,2-BENZOPYRONE
CAS: 91-64-5
MF: C9H6O2
MW: 146.14
EINECS: 202-086-7
Product Categories: FINE Chemical & INTERMEDIATES;Food & Feed ADDITIVES;Coumarins;Coumarin;Natural Plant Extract;Aromatics;Heterocycles;Pharmaceutical intermediates;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Fluorescent
Mol File: 91-64-5.mol
Coumarin Structure
 
Coumarin Chemical Properties
Melting point  68-73 °C(lit.)
Boiling point  298 °C(lit.)
density  0.935
vapor pressure  0.01 mm Hg ( 47 °C)
refractive index  1.5100 (estimate)
Fp  162 °C
storage temp.  Refrigerator
solubility  1.7g/l
form  Crystals or Crystalline Powder
color  White
PH Range Non' uorescence (9.5) to light green ' uorescence (10.5)
Water Solubility  1.7 g/L (20 ºC)
λmax 275nm
Merck  14,2562
BRN  383644
Major Application color filter, organic electroluminescent devices, liquid crystal displays, field emission displays, inks, nickel plating, detergents, deodorant for shoes, petroleum products, cigarettes, personal care products, cosmetics, sunscreen cream, perfumes, nucleic acid sequencing, antiinflammatory agent, treatment of cancer, neurotransmission disorders, bleeding disorders, cerebrovascular disease, thrombosis, hemorrhoids, rheumatic disease, arthritic disease, epilepsy, vaginitis, painkiller, teeth whitening agent, skin whitening agent, wound healing promoter
InChIKey ZYGHJZDHTFUPRJ-UHFFFAOYSA-N
CAS DataBase Reference 91-64-5(CAS DataBase Reference)
NIST Chemistry Reference Coumarin(91-64-5)
EPA Substance Registry System 2H-1-Benzopyran- 2-one(91-64-5)
 
Safety Information
Hazard Codes  Xn
Risk Statements  22-40-36/37/38-20/21/22-43
Safety Statements  36-36/37-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  1
RTECS  GN4200000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29322010
Hazardous Substances Data 91-64-5(Hazardous Substances Data)
Toxicity LD50 orally in rats, guinea pigs: 680, 202 mg/kg (Jenner)
MSDS Information
Provider Language
ACROS English
SigmaAldrich English
ALFA English
 
Coumarin Usage And Synthesis
Brief Introduction
It is also known as 1, 2-benzopyrone, cis ortho-caberillin, o-hydroxy cinnamon lactone and coumarin. It is contained in many natural plants in the form of glycosides and esters as vanillin instead of free-form. Coumarin will come out when certain plants are fermented and processed. Coumarin is found in the seeds of Dayton beans (Riccinechoides) in 1820 and is widely distributed in the plant kingdom, especially in plant species including Umbelliferae, Soybean, Rutaceae and Calyx. Seeds contain about 1.5% of the coumarin. In addition, coumarin is also contained in lavender oil, cinnamon oil and Peru balsam. Coumarin is spicy with sweet and lemongrass aroma. The aroma is emitted from the pink gum in the leaves of the fragrant beans, and the gum is made from the breakdown of the coumarin glycosides in the leaves. The aroma emitted by Sweet alfalfa is actually from the release of coumarin due to fermentation and decomposition during the stacking process. Precipitate from the ether appears as orthorhombic white pyramid or oblique sheet-like crystals with Lemongrass-type smell. It can subject to sublimation.
Chemical Properties Golden crystalline solid (fronds or rhomboid); it is sweet with black beans-like aroma, dried herbs aroma and fennel aroma. After dilution, it smells like dried straw, nuts and tobacco. It is insoluble in cold water but soluble in hot water, ethanol and chloroform, easily soluble in ether and benzene. The solubility in 100ml of water at 25 ℃ is only 0.01g; 13 7g in 100ml of ethanol at 16 ℃; 1g in 50 mL 100℃ hot water. Oral LD50: 680mg / kg for rat.
Uses used as a spice for the preparation of floral fragrances such as lavender, rosemary and rosemary, used in perfumes, cosmetics, soaps and detergents; used as flavoring agents for blending fragrances to make the aroma be lasting and unchanged; used as an electroplating additive to prevent the occurrence of pores in coating and can increase the brightness; as the flavor enhancer of printing ink and plastic; formerly used as spices and cigarettes spices, banned from 197; Since then, China had also prohibited it application in food; used as pharmaceutical raw materials.
Coumarin, as a laser dye, has an output laser range be within the blue-green region (420 ~ 570nm), has high fluorescence quantum efficiency, such as 7-ethylamino-6-methyl-4-trifluoromethyl coumarin Lactone 307), the structure is as follows:
Chemical Properties WHITE CRYSTALS OR CRYSTALLINE POWDER
Uses Pharmaceutic aid (flavor). Found in tonka beans, levender oil, woodruff, sweet clover.
Uses antineoplastic, antiinflammatory, antihyperglycaemic
Uses coumarin is considered a blood thinner, it can also increase blood flow. Some sources cite anti-oxidant capacities, as well. It is a specific plant constituent and is what creates the fragrance of freshly mowed hay. Coumarin is found in such plants as cherries, lavender, licorice, and sweet clover.
Definition ChEBI: A chromenone having the keto group located at the 2-position.
General Description Colorless crystals, flakes or colorless to white powder with a pleasant fragrant vanilla odor and a bitter aromatic burning taste.
Air & Water Reactions Insoluble in water.
Reactivity Profile Coumarin is sensitive to exposure to light. Coumarin is also sensitive to heat. Coumarin is incompatible with strong acids, strong bases and oxidizers. Coumarin is hydrolyzed by hot concentrated alkalis. Coumarin can be halogenated, nitrated and hydrogenated (in the presence of catalysts).
Health Hazard SYMPTOMS: Exposure to Coumarin may cause narcosis. It may also cause irritation and liver damage.
Fire Hazard Coumarin is combustible.
Contact allergens Coumarin is an aromatic lactone naturally occurring in Tonka beans and other plants. As a fragrance allergen, it has to be mentioned by name in cosmetics within the EU
Safety Profile Poison by ingestion, intraperitoneal, and subcutaneous routes. Questionable carcinogen with experimental tumorigenic data. Experimental teratogenic effects. Mutation data reported. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and fumes. See also KETONES and ANHYDRIDES.
Purification Methods Coumarin crystallises from ethanol or water and sublimes in vacuo at 43o [Srinivasan & deLevie J Phys Chem 91 2904 1987]. [Beilstein 17/10 V 143.]

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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career henan chemical co

Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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