Lafutidine
| Price | USD1.00 |
| Packge | 1kg |
- Min. Order:1g
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NameLafutidine
- CAS No. 118288-08-7
- EINECS No.601-513-8
- MFC22H29N3O4S
- MW431.55
- Appearancepowder to crystalWhite to Orange to Green
- Melting point 92.7-94.9°
- Boiling point 704.2±60.0 °C(Predicted)
- density 1.252±0.06 g/cm3(Predicted)
- storage temp. Sealed in dry,Store in freezer, under -20°C
- Water Solubility Insoluble in water
| Lafutidine Basic information |
| Product Name: | Lafutidine |
| Synonyms: | n-(4-(4-piperidinylmethyl)pyridyl-2-oxy)butenyl-2-(furfurylsulfinyl)acetamide;LAFUTIDINE;(+-)-2-(furfurylsulfinyl)-n-(4-(4-(piperidinomethyl)-2-pyridyl)oxy-(z)-2-but;(z)-inyl)oxy)-2-butenyl);acetamide,2-((2-furanylmethyl)sulfinyl)-n-(4-((4-(1-piperidinylmethyl)-2-pyrid;enyl)acetamide;frg-8813;LAFUTIDINE(SUBJECTTOPATENTFREE) |
| CAS: | 118288-08-7 |
| MF: | C22H29N3O4S |
| MW: | 431.55 |
| EINECS: | 1312995-182-4 |
| Product Categories: | Active Pharmaceutical Ingredients;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Other APIs |
| Mol File: | 118288-08-7.mol |
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| Lafutidine Chemical Properties |
| Melting point | 92.7-94.9° |
| CAS DataBase Reference | 118288-08-7(CAS DataBase Reference) |
| Safety Information |
| Safety Statements | 24/25 |
| HS Code | 29349990 |
| Lafutidine Usage And Synthesis |
| Description | Lafutidine is a second generation of H2-receptor antagonist. H2-receptor antagonist can strongly inhibit gastric acid secretion compared with conventional drugs such as antacids. Unlike conventional H2-receptor antagonist, lafutidine inhibits gastric acid secretion during daytime as well as nighttime in clinical studies in humans. Lafutidine also has gastroprotective activity independent of its acid antisecretory efficacy, preventing noxious agent-induced gastric mucosal injury and accelerating the repair process following gastric mucosal damage. It also protects experimentally induced reflux esophagitis, indomethacin-induced intestinal, and dextran sulfate sodium-induced colonic inflammation. Lafutidine is used for gastric and duodenal ulcers. It is also confirmed that lafutidine can be used as an empiric treatment and superior efficacy for primary care practice patients with dyspepsia. |
| References | [1] Tomohiko Shimatani, Masaki Inoue, Tomoko Kuroiwa, Jing Xu, Masuo Nakamura, Susumu Tazuma, Kazuro Ikawa, Norifumi Morikawa (2006) Lafutidine, a Newly Developed Antiulcer Drug, Elevates Postprandial Intragastric pH and Increases Plasma Calcitonin Gene-Related Peptide and Somatostatin Concentrations in Humans: Comparisons with Famotidine, Digestive Diseases and Sciences, 51, 114-120 [2] Bhupesh Dewan, Nisha Philipose (2011) Lafutidine 10 mg versus Rabeprazole 20 mg in the Treatment of Patients with Heartburn-Dominant Uninvestigated Dyspepsia: A Randomized, Multicentric Trial, Gastroenterology Research and Practice, 2011, Article ID 640685 [3] https://www.drugs.com |
| Uses | Second generation histamine H2-receptor antagonist. Antiulcerative |
| Uses | Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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