TACROLIMUS
| Price | USD1.00 |
| Packge | 1kg |
- Min. Order:1kg
- Supply Ability:Customized
- Time:2019-07-06
Product Details
- Product NameTACROLIMUS
- CAS No.109581-93-3
- EINECS No.617-559-7
- MFC44H71NO13
- MW822.05
- AppearancepowderWhite to Almost white
- storage temp. -20°C
- Melting point 127-129°
SP320
| TACROLIMUS Basic information |
| Product Name: | TACROLIMUS |
| Synonyms: | FK-506;,8s*,9e,12r*,14r*,15s*,16r*,18s*,19s*,26ar*))-;18-tetramethyl-8-(2-propenyl)-,monohydrate,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*;3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-9,10,12,;tacrolimushydrate;tsukubaenolidehydrate;FK-506 MONOHYDRATE;Tacarolimus |
| CAS: | 109581-93-3 |
| MF: | C44H69NO12 |
| MW: | 822.04 |
| EINECS: | |
| Product Categories: | Signalling |
| Mol File: | 109581-93-3.mol |
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| TACROLIMUS Chemical Properties |
| Melting point | 127-129° |
| alpha | D23 -84.4° (c = 1.02 in chloroform) |
| storage temp. | −20°C |
| solubility | DMSO: soluble20mg/mL |
| Merck | 14,9025 |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1/PG 3 |
| RTECS | KD4201200 |
| HazardClass | 6.1 |
| PackingGroup | III |
| Toxicity | LD50 i.p. in mice: >200 mg/kg (Kino); LD50 in male, female rats (mg/kg): 57.0, 23.6 i.v.; 134, 194 orally (Ohara) |
| TACROLIMUS Usage And Synthesis |
| Uses | immune suppressant, antifungal |
| Definition | ChEBI: A hydrate that is the monohydrate form of tacrolimus. |
| Biological Activity | Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo . |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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