Nelarabine
| Price | USD1.00 |
| Packge | 1kg |
- Min. Order:1kg
- Supply Ability:Customized
- Time:2019-07-06
Product Details
- Product NameNelarabine
- CAS No.121032-29-9
- EINECS No.1806241-263-5
- MFC11H15N5O5
- MW297.27
- AppearanceSolidWhite
- Melting point 209-217°
- Boiling point 721.0±70.0 °C(Predicted)
- density 1.98±0.1 g/cm3(Predicted)
- storage temp. 2-8°C(protect from light)
SP237
| Nelarabine Basic information |
| Product Name: | Nelarabine |
| Synonyms: | NELARABINE;Nelzarabine [USAN];Nelzarabine;9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine;(2R,3R,4S,5R)-2-(2-aMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)-tetrahydrofuran-3,4-diol;Nelarabine (Arranon);506u;9-β-D-Arabinofuranosyl-6-Methoxy-9H-purin-2-aMine |
| CAS: | 121032-29-9 |
| MF: | C11H15N5O5 |
| MW: | 297.27 |
| EINECS: | 1806241-263-5 |
| Product Categories: | Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;5g,10g,25g,100g;ARRANON;Anti-cancer&immunity;API;Inhibitors |
| Mol File: | 121032-29-9.mol |
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| Nelarabine Chemical Properties |
| Melting point | 209-217° |
| alpha | D20 +55.9° (c = 0.27 in DMF) |
| CAS DataBase Reference | 121032-29-9(CAS DataBase Reference) |
| Safety Information |
| Nelarabine Usage And Synthesis |
| Physical properties | White or almost white crystalline powder. This product is slightly soluble in water, the solubility in water is about 8-9mg/ml (25 ℃, PH = 4~10). |
| Developed by GlaxoSmithKline | Nelarabine is a prodrug for deoxyguanosine analogue ——9-beta-D-arabinofuranosyl guanine (ara-G). Nelarabine demethylates in the role of adenosine deaminase (ADA) and turns into ara-G. Then, It turns into active ara-G triphosphate (ara-GTP) in the role of the deoxyguanosine kinase and deoxycytidine kinase and under the action of the monophosphorylation pathway. Ara-GTP can accumulate in leukemia cells, and bind to DNA to inhibit DNA synthesis, and accelerate leukemia cell death. In addition, the anti-cancer mechanism of Nelarabine may also be related to its cytotoxicity and somatic toxicity. Nelarabine was first successfully developed by GlaxoSmithKline. On October 28, 2005 under the approval of the US Food and Drug Administration, it became a new drug for curing T-cell acute lymphoblastic leukemia (T-ALL) and T-Cells lymphoblasticlymphoma (T-LBL) which are resistant to at least two types of chemotherapy regimens or relapsed after initial treatment. This new drug officially listed in the United States in 2006. This product didn’t apply for patent and administrative protection in China, so the development of this product does not exist intellectual property issues. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Inquiry
- 2024-02-21
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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