Z-VAD-FMK
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1G
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NameZ-VAD-FMK
- CAS No.187389-52-2
- MFC22H30FN3O7
- MW467.49
- Appearancepowderwhite
- storage temp. -20°C
- density 1.214±0.06 g/cm3 (20 ºC 760 Torr)
- Boiling point 732.4±60.0 °C(Predicted)
- Melting point >190°C (dec.)
AD68
| Z-VAD-FMK Basic information |
| Product Name: | Z-VAD-FMK |
| Synonyms: | Z-VADC(OME)-FMK;methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-phenylmethoxycarbonylamino-butanoyl]amino]propanoyl]amino]-4-oxo-pentanoate;N-BENZYLOXYCARBONYL-VAL-ALA-ASP FLUOROMETHYL KETONE;Z-VAD-FLUOROMETHYLKETONE;Z-VAD-FMK;Z-VAD-FMK, METHYL ESTER;Z-VAD(OME)-FLUOROMETHYLKETONE;Z-VAD(OME)-FMK |
| CAS: | 187389-52-2 |
| MF: | C21H28FN3O7 |
| MW: | 453.46 |
| EINECS: | |
| Product Categories: | Caspases/Apoptosis;Caspase/Related Products;Apoptosis;peptides;API;Inhibitors |
| Mol File: | Mol File |
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| Z-VAD-FMK Chemical Properties |
| density | 1.214±0.06 g/cm3 (20 ºC 760 Torr) |
| Fp | 396.7℃ |
| storage temp. | −20°C |
| solubility | DMSO: 20 mg/mL |
| form | powder |
| color | white |
| InChIKey | MIFGOLAMNLSLGH-QOKNQOGYSA-N |
| Safety Information |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| Z-VAD-FMK Usage And Synthesis |
| Uses | Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical] |
| Biological Activity | Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo . |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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