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Lornoxicam
Lornoxicam

Lornoxicam

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameLornoxicam
  • CAS No.70374-39-9
  • EINECS No.630-354-7
  • MFC13H10ClN3O4S2
  • MW371.82
  • Appearancepowderfaint yellow to dark yellow
  • Melting point 225-230°C (dec.)
  • storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
  • density 1.742±0.06 g/cm3(Predicted)

AD68

Lornoxicam Basic information
Description References
Product Name: Lornoxicam
Synonyms: LORNOXICAM;AKOS 93662;6-CHLORO-4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE;2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide,6-chloro-4-hydroxy-2-methyl-n-2-py;chlortenoxicam;ridinyl-,1,1-dioxide;6-Chloro-4-hydroxy-2-methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide-1,1-dioxide;LornoxicamConsultedStandard
CAS: 70374-39-9
MF: C13H10ClN3O4S2
MW: 371.82
EINECS: 1308068-626-2
Product Categories: APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Fused Ring Systems;API;AVITA;Other APIs
Mol File: 70374-39-9.mol
Lornoxicam Structure
 
Lornoxicam Chemical Properties
Melting point  225-230°C (dec.)
storage temp.  -20°C Freezer
solubility  DMSO: >5mg/mL (warmed)
pka pKa2 4.7(at 25℃)
color  faint yellow to dark yellow
Merck  14,5582
CAS DataBase Reference 70374-39-9(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xi,T+
Risk Statements  36/37/38-28
Safety Statements  26-36-45-36/37-28
RIDADR  UN 2811 6.1 / PGII
RTECS  XJ9095000
HazardClass  IRRITANT
PackingGroup  II
Toxicity LD50 orally in mice, rats, rabbits, dogs, monkeys: >10 mg/kg (Pruss)
MSDS Information
 
 
Lornoxicam Usage And Synthesis
Description Lornoxicam (Trade name: “Xefo”) belongs to a non-steroidal anti-inflammatory drug. As a kind of oxicam class drug, it has analgesic, anti-inflammatory and antipyretic properties. It can be used for the treatment of various type of acute mild to moderate pain which results from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and rheumatic diseases. Lornoxicam is capable of potently inhibiting the prostaglandin biosynthesis process, making it have highly pronounced efficacy. The exact mechanism of Lornoxicam is not exactly understood. However, it is indicated that Lornoxicam can inhibit the prostaglandin and thromboxane synthesis by inhibiting both COX-1 and COX-2, leading to reduction of inflammation, pain, fever, and swelling.
References https://www.drugbank.ca/drugs/DB06725
https://en.wikipedia.org/wiki/Lornoxicam
Chemical Properties Crystalline Solid
Uses keratolytic, antiacne, antineoplastic
Uses ocular vasoconstrictor
Uses For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.
Uses Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic
Definition ChEBI: A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for th treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.
 
 

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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