Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
China United Kingdom South Korea Germany Japan India
Inquriy
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomecompanyCetirizine hydrochloride
Cetirizine hydrochloride
Cetirizine hydrochloride

Cetirizine hydrochloride

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameCetirizine hydrochloride
  • CAS No. 83881-52-1
  • EINECS No.620-533-8
  • MFC21H26Cl2N2O3
  • MW425.35
  • Appearancepowderwhite to beige
  • Melting point 110-115°C
  • storage temp. 2-8°C
  • Water Solubility Soluble in water, DMSO, ethanol, and methanol.

AD68

Cetirizine hydrochloride Basic information
Description References
Product Name: Cetirizine hydrochloride
Synonyms: (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)aceticaciddihydro;2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride;2-[4-(4-Chlorobenzhy;Cetrizide;Cetirizine Hydrochloride (250 mg);Alercet;Alerid;Cesta
CAS: 83881-52-1
MF: C21H26Cl2N2O3
MW: 425.35
EINECS: 222-225-5
Product Categories: Histamine receptor;Aromatics;Heterocycles;Metabolites & Impurities;API;Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;DOPRAM;Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 83881-52-1.mol
Cetirizine hydrochloride Structure
 
Cetirizine hydrochloride Chemical Properties
Melting point  110-115°C
storage temp.  Desiccate at RT
solubility  H2O: soluble5mg/mL, clear
color  white to beige
Water Solubility  Soluble in water, DMSO, ethanol, and methanol.
Merck  14,2022
CAS DataBase Reference 83881-52-1(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
RIDADR  3249
WGK Germany  3
RTECS  AG0977500
HazardClass  6.1(b)
PackingGroup  III
Cetirizine hydrochloride Usage And Synthesis
Description Cetirizine hydrochloride is an orally-active and selective histamine (H1)-receptor antagonist. It is a second-generation antihistamine and a human metabolite of hydroxyzine. Three important features of cetirizine are: a high specificity fort he H1-receptor; a low need for metabolism, and the existence of non-H1-dependent activities on cells involved in the pathogenesis of allergy.
Cetirizine is used to treat seasonal allergic rhinitis (SAR), perennial allergic rhinitis, useful in treating urticaria and atopic dermatitis. Cetirizine possesses also mild anti-inflammatory effects.
References [1] E. J. Corey and Christopher J. Helal, Catalytic Enantioselective Synthesis of the Second-Generation Histamine Antagonist Cetirizine Hydrochloride, Tetrahedron Letters, 1996, vol. 37, 4837-4840
[2] Jay M. Portnoy and Chitra Dinakar, Review of cetirizine hydrochloride for the treatment of allergic disorders, Journal of Expert Opinion on Pharmacotherapy, 2004, vol. 5, 125-135
Chemical Properties Crystalline Solid
Uses respiratory stimulant
Uses A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
Uses long acting calcium channel blocker
Uses Antihistaminic
Biological Activity Histamine H 1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μ M. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo .
 
 

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

Recommended supplier

career henan chemical co

Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
HomePage About Us Contact us Terms Privacy Chemicalbook
Land Line: 040 - 40102781 Mobile contact: +91 9550333722