Probucol
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1G
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NameProbucol
- CAS No.23288-49-5
- EINECS No.245-560-9
- MFC31H48O2S2
- MW516.84
- AppearanceneatWhite to Off-White
- storage temp. Keep in dark place,Sealed in dry,Room Temperature
- Melting point 126-128°C
- Boiling point 571.58°C (rough estimate)
- density 1.0008 (rough estimate)
AD68
| Probucol Basic information |
| Product Name: | Probucol |
| Synonyms: | PROBUCOL;4,4’-((1-methylethylidene)bis(thio))bis(2,6-bis(1,1-dimethylethyl)-pheno;biphenabid;bisbid;bisphenabid;dh581;4,4'-ISOPROPYLIDINEDITHIO-BIS-(2,6-DI-TERT-BUTYL)PHENOL;4-({1-[(4-hydroxy-3,5-di-t-butylphenyl)thio]-1-methylethyl}thio)-2,6-di-t-butylphenol |
| CAS: | 23288-49-5 |
| MF: | C31H48O2S2 |
| MW: | 516.84 |
| EINECS: | 245-560-9 |
| Product Categories: | Cardiovascular;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API;LORELCO;Isolabel;Cardiovascular APIs |
| Mol File: | 23288-49-5.mol |
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| Probucol Chemical Properties |
| Melting point | 126-128°C |
| Boiling point | 571.58°C (rough estimate) |
| density | 1.0008 (rough estimate) |
| refractive index | 1.5341 (estimate) |
| storage temp. | Desiccate at +4°C |
| Merck | 14,7755 |
| CAS DataBase Reference | 23288-49-5(CAS DataBase Reference) |
| Safety Information |
| RTECS | AL3705000 |
| Probucol Usage And Synthesis |
| Description | Probucol is a kind of bis-phenol antioxidant with anti-hyperlipidemic activity. It had been initially developed for the treatment of coronary artery disease. However, its clinical trials were stopped after people found that it could lower the HDL and LDL cholesterol in patients of a history of heart disease. Probucol exerts its effect through accelerating the fractional rate of low-density (LDL) catabolism which is in the final pathway of cholesterol elimination inside the body. It may also inhibit the early stage of cholesterol biosynthesis and dietary cholesterol absorption. |
| Chemical Properties | White Solid |
| Uses | antihyperlipidemic |
| Uses | Probucol is an antilipemic. |
| Uses | anti-hyperlipoproteinemic |
| Uses | An antioxidant, anti-inflammatory, and hypocholesterolemic agent which inhibits atherogenesis in murine models. |
| Definition | ChEBI: A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high l vels of cholesterol in blood. |
| Biological Activity | Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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