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Febuxostat
Febuxostat

Febuxostat

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameFebuxostat
  • CAS No.144060-53-7
  • EINECS No.682-158-6
  • MFC16H16N2O3S
  • MW316.37
  • AppearancepowderWhite to Off-White
  • Melting point 238-239°(dec.)
  • storage temp. 2-8°C
  • Boiling point 536.6±60.0 °C(Predicted)
  • density 1.31±0.1 g/cm3(Predicted)

AD68

Febuxostat Basic information
Indications and Usage Mechanisms of Action
Product Name: Febuxostat
Synonyms: Febuxostat (Uloric);FBX;Uloric;Febuxostat (TEI-6720);Febuxostat Tablets;FEBUXOSTAT API;Febuxostat (This product is unavailable in the U.S.);Febuxostat Tabletshehe
CAS: 144060-53-7
MF: C16H16N2O3S
MW: 316.37
EINECS: 1308068-626-2
Product Categories: zjh;API;Febuxostat;TRILIPIX;Other APIs;eterocycles;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 144060-53-7.mol
Febuxostat Structure
 
Febuxostat Chemical Properties
Melting point  238-239°(dec.)
storage temp.  Refrigerator
Merck  14,3948
CAS DataBase Reference 144060-53-7(CAS DataBase Reference)
 
Safety Information
RTECS  XJ3675310
MSDS Information
 
 
Febuxostat Usage And Synthesis
Indications and Usage Febuxostat is a new generation xanthine oxidase inhibitor developed by Tejin Co. (Japan,) used clinically for for long-term treatment of hyperuicemia (gout,) a new and highly effective non-purine selective inhibitor of xanthine oxidase. It is not recommended for gout patients without hyperuricemia.
Mechanisms of Action The production of uric acid in the body is related to purine metabolism. In the last step of the production, hypoxanthine produces xanthine through the action of xanthine oxidoreductase (XOR), finally producing uric acid. Inhibiting the activity of this enzyme can effectively reduce the production of uric acid. Xanthine oxidase is the main enzyme promoting uric acid production. Through highly selective inhibition of oxidized and reduced xanthine oxidase, Febuxostat can reduce synthesis of uric acid, decreasing its concentration and effectively treating gout . Through liver metabolism, Xanthine oxidase does not rely on renal excretion, so patients with moderate to severe liver and kidney dysfunction do not need to reduce dosages. Febuxostat is a non-purine XOR inhibitor, so it is very safe.
Chemical Properties Crystalline Solid
Uses antihyperlipidemic
Uses Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
Uses Febuxostat is primarily indicated in conditions like Gout, Hyperuricemia
 

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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career henan chemical co

Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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