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Desloratadine
Desloratadine

Desloratadine

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameDesloratadine
  • CAS No.100643-71-8
  • EINECS No.638-878-8
  • MFC19H19ClN2
  • MW310.82
  • AppearancepowderWhite to Light orange to Yellow
  • Melting point 150-151°C
  • storage temp. 2-8°C
  • Boiling point 467.9±45.0 °C(Predicted)
  • density 1?+-.0.06 g/cm3(Predicted)

AD68

Desloratadine Basic information
Product Name: Desloratadine
Synonyms: DESLORATADINE;DESLORATIDINE;8-chloro-6,11-dihydro-11-(4-piperdinylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine;8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDINYLIDENE)-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE;AKOS 92131;SCH-34117;Aerius;Dis-loratadine
CAS: 100643-71-8
MF: C19H19ClN2
MW: 310.82
EINECS: 1308068-626-2
Product Categories: Active Pharmaceutical Ingredients;Antihistaminic;Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Heterocycles;Metabolites & Impurities;API;FLUVENT;Other APIs;Inhibitors
Mol File: 100643-71-8.mol
Desloratadine Structure
 
Desloratadine Chemical Properties
Melting point  150-151°C
storage temp.  2-8°C
solubility  DMSO: >10mg/mL
Merck  14,2922
CAS DataBase Reference 100643-71-8(CAS DataBase Reference)
 
Safety Information
RTECS  DE8011000
MSDS Information
 
 
Desloratadine Usage And Synthesis
Description Desloratadine is a second generation of tricyclic antihistamine. It is a H1-receptor antagonist which has anti-inflammatory activity. Its affinity to the H1 receptor is higher than most other H1-receptor antagonists. Desloratadine works by blocking a certain natural substance (histamine) which is produced during an allergic reaction. Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Desloratadine is used to treat nasal and non-nasal symptoms (watery eyes, runny nose, itching eyes/nose, sneezing, and itching) of seasonal allergic rhinitis. It is also used to relieve chronic itching caused by hives.
Chemical Properties Beige Solid
Uses A histamine H1-receptor antagonist. An active metabolite of Loratadine
Uses Nonsedating-type histamine H1-receptor antagonist. An active metabolite of Loratadine. Also inhibits generation and release of inflammatory mediators from basophils and mast cells.
Uses antiinflammatory
Uses For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.
Definition ChEBI: Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis nd chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.
 

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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career henan chemical co

Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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