Topotecan

Price	USD1.00
Packge	1KG

Product Details

Product Name Topotecan
CAS No. 123948-87-8
EINECS No.687-471-1
MFC23H23N3O5
MW421.45
Appearanceliquidyellow
Melting point −114 °C(lit.)
storage temp. Sealed in dry,Store in freezer, under -20°C
Boiling point >100 °C(lit.)
density 1.2 g/mL at 25 °C(lit.)

AD68

Topotecan Basic information

Camptothecin anticancer drugs Uses Production methods

Product Name:	Topotecan
Synonyms:	hycamptamine;HYDROGEN CHLORIDE, BUTANOL REAGENT;HYDROGEN CHLORIDE GAS;HYDROGEN CHLORIDE, METHANOL REAGENT;HYDROGEN CHLORIDE, METHANOL REAGENT 10;HYDROGEN CHLORIDE, METHANOL REAGENT 5;HYDROCHLORIC ACID,1.1M;HYDROCHLORIC ACID, 1N
CAS:	123948-87-8
MF:	C23H23N3O5
MW:	421.45
EINECS:	231-595-7
Product Categories:	APIs;API
Mol File:	123948-87-8.mol

Topotecan Chemical Properties

Melting point	−114 °C(lit.)
Boiling point	>100 °C(lit.)
density	1.2 g/mL at 25 °C(lit.)
vapor density	1.3 (vs air)
vapor pressure	613 psi ( 21.1 °C)
Fp	12 °C
storage temp.	2-8°C
solubility	H₂O: soluble
form	liquid
color	yellow
CAS DataBase Reference	123948-87-8(CAS DataBase Reference)

Safety Information

Hazard Codes	T,C,F,Xi
Risk Statements	36/37/38-67-35-20-11-34-48-46-36
Safety Statements	26-45-36/37/39-37/39-36-22-24/25-16-7
RIDADR	UN 3286 3/PG 2
WGK Germany	2
RTECS	MW4025000
F	3
HazardClass	8
PackingGroup	II

Topotecan Usage And Synthesis

Camptothecin anticancer drugs	Camptothecin anticancer drugs are alkaloids or derivatives of them after the structure transformation raised from deciduous plant Davidia involucrata Camptotheca acuminate seed or root bark. Clinical application of them mainly includes camptothecin,hydroxycamptothecin, topotecan and irinotecan. Topotecan is a water-soluble semi-synthetic derivative of camptothecin,it is a topoisomerase I inhibitor, inhibiting DNA single strand DNA scission reconnect to damage DNA, its cytotoxicity occurs in cancer cell division S phase, it is an s phase cell cycle specific drug . In vivo it is a two-compartment model,it can be quickly distributed to the liver, kidneys and other parts , of a single intravenous infusion 1.5mg/m2 every 30 minutes , t1/2αis 4.1 to 8.1 minutes, plasma protein binding rate is 6.6%~21.3%,it can go into the cerebrospinal fluid. Most of it is excreted by the kidneys, a small part of it is excreted by the bile, within 12 hours, 90% of it is excreted.Clearance rate of renal dysfunction decreases.it is clinically used for the treatment of small cell lung cancer (SCLC), and advanced ovarian cancer, because it can penetrate the blood-brain barrier ,it has a certain effect on the central nervous system cancer and brain metastases. Usage: every single drug dose 1.2mg/m2 intravenous infusion once a day, once every 5 days, 21 days is 1 cycle, there is the need to reduce the dose when in combination with other anticancer drugs. The main adverse events are hematologic toxicity, white blood cells, platelets and hemoglobin decrease; non-hematologic toxicity adverse events are loss of appetite, nausea, vomiting, hair loss, stomatitis, diarrhea, headache, fever, constipation, transient elevated transaminase; occasionally breathing difficulties, hematuria, andelectrocardiogram abnormalities. Severe bone marrow suppression are hanged. Monitor the blood and adjust the dose in accordance with changes in blood during the treatment , if necessary, granulocyte colony stimulating factor (G-CSF), and transfusion of blood components may be given . The above information is edited by the chemicalbook of Tian Ye.
Uses	Anti-cancer drugs.It can be used alone for the treatment of initially or continuously ineffective chemotherapy metastatic ovarian cancer.
Production methods	Compound (I) with 37% formaldehyde and 40% dimethylamine,after aminomethylation in acetic acid, produces the product.
Chemical Properties	Off-white Cryst
Uses	antineoplastic;DNA topoisomerase type 1 inhibitor
Definition	ChEBI: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

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Product Details

Company Profile Introduction

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