Promethazine hydrochloride
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1G
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NamePromethazine hydrochloride
- CAS No.58-33-3
- EINECS No.200-375-2
- MFC17H21ClN2S
- MW320.88
- InChIKeyXXPDBLUZJRXNNZ-UHFFFAOYSA-N
- AppearanceneatWhite to Almost white
- Melting point 230-232°C
- storage temp. 2-8°C
AD68
| Promethazine hydrochloride Basic information |
| Product Name: | Promethazine hydrochloride |
| Synonyms: | 10-(2-dimethylamino-1-propyl)phenothiazine hydrochloride;PROMETHAZINE HCL;PROMETHAZINE HYDROCHLORIDE;PHENERGAN;10-(2-(dimethylamino)propyl)phenothiazinemonohydrochloride;10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochloride;10-(2-dimethylaminopropyl)phenothiazinehydrochloride;10-(3-dimethylaminoisopropyl)phenothiazinehydrochloride |
| CAS: | 58-33-3 |
| MF: | C17H21ClN2S |
| MW: | 320.88 |
| EINECS: | 200-375-2 |
| Product Categories: | Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Histamine receptor;API;COLACE;Inhibitors |
| Mol File: | 58-33-3.mol |
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| Promethazine hydrochloride Chemical Properties |
| Melting point | 230-232°C |
| Fp | 9℃ |
| storage temp. | Refrigerator |
| λmax | 297nm(H2O)(lit.) |
| Merck | 14,7786 |
| InChIKey | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
| CAS DataBase Reference | 58-33-3(CAS DataBase Reference) |
| EPA Substance Registry System | 10H-Phenothiazine- 10-ethanamine, N,N,.alpha.-trimethyl-, monohydrochloride(58-33-3) |
| Safety Information |
| Hazard Codes | Xn,N |
| Risk Statements | 22-36/37/38-51/53-43-20/22 |
| Safety Statements | 26-36-61-60-36/37/39-28-22 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | SO8225000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 i.v. in mice: 55.0 mg/kg (Rajsner) |
| Promethazine hydrochloride Usage And Synthesis |
| Chemical Properties | White Solid |
| Uses | Antihistaminic, antiemetic, CNS depressant |
| Uses | stool softener |
| Uses | For the treatment of allergic disorders, and nausea/vomiting. |
| Definition | ChEBI: The hydrochloride salt of promethazine. |
| Uses | Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively. Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea. |
| General Description | Odorless white to faint yellow crystalline powder. Bitter taste. A 10% solution in water has a pH of 3.5-5.0. |
| Air & Water Reactions | Slowly oxidizes in air, acquiring a blue color. Also turns blue on exposure to moisture. Water soluble. |
| Reactivity Profile | Promethazine hydrochloride is sensitive to light. In aqueous solution, Promethazine hydrochloride is degraded by heat and light (more rapidly in air or oxygen). Incompatible with alkalis and alkaline solutions such as those of aminophylline, soluble barbiturates and phenytoin sodium. Iron(III) and copper(III) accelerate the degradation . |
| Fire Hazard | Flash point data for Promethazine hydrochloride are not available; however, Promethazine hydrochloride is probably combustible. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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