Phenylbutazone
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1G
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NamePhenylbutazone
- CAS No.50-33-9
- EINECS No.200-029-0
- MFC19H20N2O2
- MW308.37
- InChIKeyVYMDGNCVAMGZFE-UHFFFAOYSA-N
- AppearancePowderWhite to almost white
- Water Solubility <0.1 g/100 mL at 23.5 ºC
- Melting point 106-108 °C (lit.)
- storage temp. 2-8°C
- Boiling point 448.76°C (rough estimate)
- density 1.1591 (rough estimate)
AD68
| Product Name: | Phenylbutazone |
| Synonyms: | PHENYLBUTAZONE;1,2-Diphenyl-2,3-dioxo-4-N-butylpyrazoline;1,2-Diphenyl-3,5-dioxo-4-butylpyrazolidine;1,2-Diphenyl-4-butyl-3,5-dioxopyrazolidine;1,2-Diphenyl-4-butyl-3,5-pyrazolidinedione;3,5-dioxe-4buty-1,diphenyl-pyrazolidine;3,5-dioxo01,2-diphenyl-4-m-butyl-pyrazolidine;3,5-Dioxo-1,2-diphenyl-4-N-butyl-pyrazolidin |
| CAS: | 50-33-9 |
| MF: | C19H20N2O2 |
| MW: | 308.37 |
| EINECS: | 200-029-0 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles;Inhibitors;API;AZOLID |
| Mol File: | 50-33-9.mol |
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| Phenylbutazone Chemical Properties |
| Melting point | 104-107 °C |
| Boiling point | 448.76°C (rough estimate) |
| density | 1.1591 (rough estimate) |
| refractive index | 1.6140 (estimate) |
| storage temp. | -20°C Freezer |
| form | Powder |
| pka | 4.5(at 25℃) |
| color | White to almost white |
| Water Solubility | <0.1 g/100 mL at 23.5 ºC |
| Merck | 14,7277 |
| BRN | 290080 |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| InChIKey | VYMDGNCVAMGZFE-UHFFFAOYSA-N |
| CAS DataBase Reference | 50-33-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenylbutazone(50-33-9) |
| EPA Substance Registry System | 3,5-Pyrazolidinedione, 4-butyl-1,2-diphenyl-(50-33-9) |
| Safety Information |
| Hazard Codes | Xn,T,F |
| Risk Statements | 36/37/38-20/21/22-42/43-45-36-11 |
| Safety Statements | 36/37/39-26-45-22-53-36/37-16 |
| RIDADR | 3249 |
| RTECS | UQ8225000 |
| TSCA | Yes |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Hazardous Substances Data | 50-33-9(Hazardous Substances Data) |
| Phenylbutazone Usage And Synthesis |
| Abstract | Phenylbutazone, often referred to as "bute,"is a nonsteroidal anti-inflammatory, antipyretic, and analgesic drug (NSAID) for the short-term treatment of pain and fever results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis. Phenylbutazone has been removed from the United States market due to the availability of newer drugs with less adverse effects. Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including injury, menstrual cramps, arthritis and other musculoskeletal conditions. |
| Chemical Property | It is soluble in acetone, chloroform or benzene freely; soluble in ethanol or ether; hardly soluble in water; soluble in sodium hydroxide solution. |
| Mechanism of action | Recent studies have found that the generating mechanism from phenylbutazone anti-inflammatory, analgesic and anti-rheumatic effect is not due to pituitary-adrenal excitement may be due to drugs that inhibit the generation of inflammatory tissue inflammation related active substances, such as synthesis of prostaglandins, white blood cells activities and transfer, release and activity of lysosomal enzymes; pain may also inhibit prostaglandin synthesis results. |
| Pharmacokinetic Study | Oral absorption effect is quickly and completely, reached the peak plasma concentration after about 2 hours. Plasma protein binding rate is 98%. The apparent volume of distribution is 0.12L/kg, such as increasing the dose, volume of distribution has also increased, but the blood concentration does not increase. Therefore, when using repeatedly, the steady-state plasma concentration does not increase linearly. The half-life is 56 to 86 hours. It can cross the placenta into the milk. This product is metabolized by the liver, metabolites is hydroxy phenylbutazone and γ-hydroxy phenylbutazone, still active, The final metabolites are excreted in urine and a small amount of bile is excreted through the urine. |
| Attention and Taboo | The side effects of phenylbutazone incidence rate is about 10%~20%, gastrointestinal irritation can cause nausea, vomiting, abdominal pain, constipation, overdose can cause peptic ulcer, blood in the stool. Damages also occur in other systems, such as rash, dizziness, hematuria, hepatitis, etc. Inhibit the bone marrow caused by neutropenia, or even aplastic anemia, such as the timely withdrawal is more recoverable and therefore should be ground check blood, no effect by 1 week, should not be reused. And double coumarin anticoagulants, sulfonamides, tolbutamide hypoglycemic drugs, increase the plasma concentration, toxicity increases. Sodium, chlorine retention effect, hypertension, edema, heart failure patients cannot use it and limit salt intake during the treatment. Patients with weak liver, osteoporosis, and kidney as well as drug allergy history are contraindicated or appropriate caution. |
| Preparation | Cyclization reaction of hydrogenated azobenzene and diethylmalonic acid diethyl: hydrazobenzene, butyl diethyl malonate, sodium sulfite and methanol are heated with severe reflux 1.5h, born in Bute salt, acidified with acetic acid to give Bute. |
| Acute toxicity | oral-rat LD50: 245 mg/kg; Oral-Mouse LD50: 270 mg/kg Irritation Data: Eye – rabbit, 100 mg, moderate |
| Flammability hazard properties | thermal decomposition emitted poisonous nitrogen oxides fumes |
| Storage characteristics | Treasury ventilation low-temperature drying; and food raw materials stored separately |
| Extinguishing agent | Water, carbon dioxide, dry powder, foam |
| Chemical Properties | Off-Whtie Solid |
| Uses | For the treatment of backache and ankylosing spondylitis |
| Uses | An inhibitor of Cox. |
| Uses | A non-steroidal anti-inflammatory compound. An inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase |
| Uses | Phenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX. Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 μM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 μM for COX and prostacyclin synthase, respectively. |
| General Description | Odorless white or off-white crystalline powder. Tasteless at first, but slightly bitter aftertaste. pH (aqueous solution) 8.2. |
| Air & Water Reactions | Phenylbutazone is relatively stable at ambient temperatures. Aqueous decomposition of Phenylbutazone occurs by hydrolysis and oxidation. Insoluble in water. |
| Reactivity Profile | Phenylbutazone is incompatible with strong oxidizers, strong acids and strong bases. . |
| Fire Hazard | Flash point data for Phenylbutazone are not available; however, Phenylbutazone is probably combustible. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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