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Fexofenadine hydrochloride
Fexofenadine hydrochloride

Fexofenadine hydrochloride

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameFexofenadine hydrochloride
  • CAS No.153439-40-8
  • EINECS No.604-906-2
  • MFC32H40ClNO4
  • MW538.13
  • Appearancepowderwhite to beige
  • Melting point 148-150oC
  • storage temp. 2-8°C

AD68

Fexofenadine hydrochloride Basic information
Description References
Product Name: Fexofenadine hydrochloride
Synonyms: α,α-dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]benzeneacetic acid;Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride;MDL 16455A;Telfast;Telfast BD;2-[4-[1-Hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoic acid hydrochloride;Allegra;Fexofenadine hydrochloride
CAS: 153439-40-8
MF: C32H40ClNO4
MW: 538.12
EINECS: 1308068-626-2
Product Categories: Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Aromatics;Heterocycles;Metabolites & Impurities;API
Mol File: 153439-40-8.mol
Fexofenadine hydrochloride Structure
 
Fexofenadine hydrochloride Chemical Properties
Melting point  148-150oC
RTECS  CY1633377
storage temp.  −20°C
solubility  Soluble in Dimethyl sulfoxide (50 mM), and methanol.
color  white to beige
Merck  14,4068
InChIKey RRJFVPUCXDGFJB-UHFFFAOYSA-N
CAS DataBase Reference 153439-40-8(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
MSDS Information
 
 
Fexofenadine hydrochloride Usage And Synthesis
Description Fexofenadine hydrochloride (trade name: Allegra) belongs to a second-generation antihistamine pharmaceutical drug. It is mainly used for the treatment of allergy symptoms including watery eyes, hay fever, nasal congestion, urticaria, runny nose, itching eyes/nose, sneezing, hives, and itching. It is a kind of selectively peripheral H1 blocker. Its mechanism of action in vivo is through preventing the histamine-mediated activation of the H1 receptors, thus alleviating the symptoms related to allergy. Compared to the first-generation antihistamine drug, it is less prone to penetrate the blood-brain barrier, reducing the possibility to cause side effects such as drowsiness.
References http://www.rxlist.com/allegra-drug/consumer-uses.htm
https://en.wikipedia.org/wiki/Fexofenadine
Chemical Properties Off-White Crystalline Solid
Uses A metabolite of of terfenadine, a H1-Histamine receptor antagonist
Uses The active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist.
Uses Antihistaminic;histamine H1-receptor antagonist
Uses Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.[Cayman Chemical]
Biological Activity Selective histamine H 1 receptor antagonist (pK i = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects.
 

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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