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Propylparaben
Propylparaben

Propylparaben

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NamePropylparaben
  • CAS No.94-13-3
  • EINECS No.202-307-7
  • MFC10H12O3
  • MW180.2
  • InChIKeyQELSKZZBTMNZEB-UHFFFAOYSA-N
  • AppearanceCrystalline PowderWhite
  • density 1.0630
  • Water Solubility <0.1 g/100 mL at 12 ºC
  • Boiling point 133°C
  • storage temp. Sealed in dry,Room Temperature
  • Melting point 95-98 °C(lit.)

AD68

Propylparaben Basic information
Chemical properties Uses content analysis Toxicity usage limits Production methods Hazards & Safety Information
Product Name: Propylparaben
Synonyms: Propyl 4-hydroxybenzoate, 99+% 500GR;Propyl 4-hydroxybenzoate, 99+% 5GR;Propyl 4-hydroxybenzo;Proply p-Hydroxybenzoate;Propyl 4-Hydroxybenzoate, 99.0%(T);Propyl 4-hydroxybenzoate standard solution;4-Hydroxybenzoic acid-propyl ester Solution, 100ppm;Propyl 4-hydroxybenzoate Vetec(TM) reagent grade, 98%
CAS: 94-13-3
MF: C10H12O3
MW: 180.2
EINECS: 202-307-7
Product Categories: API;Other APIs;Cosmetics;Pharmaceutical Raw Materials;Aromatic Esters;Aromatics
Mol File: 94-13-3.mol
Propylparaben Structure
 
Propylparaben Chemical Properties
Melting point  95-98 °C(lit.)
Boiling point  133°C
density  1.0630
refractive index  1.5050
FEMA  2951 | PROPYL P-HYDROXYBENZOATE
Fp  180°(356°F)
storage temp.  0-6°C
solubility  ethanol: soluble0.1M, clear, colorless
form  Crystalline Powder
color  White
Water Solubility  <0.1 g/100 mL at 12 ºC
Merck  14,7866
BRN  1103245
Stability: Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey QELSKZZBTMNZEB-UHFFFAOYSA-N
CAS DataBase Reference 94-13-3(CAS DataBase Reference)
NIST Chemistry Reference N-propyl-p-hydroxy-benzoate(94-13-3)
EPA Substance Registry System Benzoic acid, 4-hydroxy-, propyl ester(94-13-3)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-24/25-36
WGK Germany  1
RTECS  DH2800000
TSCA  Yes
HS Code  29182930
Hazardous Substances Data 94-13-3(Hazardous Substances Data)
Propylparaben Usage And Synthesis
Chemical properties Propylparaben is a colorless and fine crystalline or white crystalline powder, almost odorless and with slightly astringent.Soluble in ethanol, ethyl ether, acetone and other organic solvents, slightly soluble in water.
Uses 1. Propylparaben Used as preservatives and antioxidants, and also used in the pharmaceutical industry
2. Used as the antimicrobial preservative in pharmaceuticals and cosmetics 
3. According to ethyl p-hydroxybenzoate (17007)
4. Used as antiseptic and antimicrobial.
5. Used as the preservatives of food, cosmetics and medicines.
content analysis Same with Method 1 in "Butyl p-hydroxybenzoate (07002)". 
In calculation, per mL of 1 mol/L sodium hydroxide corresponds to 180.2mg of this goods (C10Hl2O8).
Toxicity Adl  0-10 mg/kg (FAO/WHO, 2001).
LD50  3.7g/kg (mouse, oral).
GRAS  (FDA, § 184.1670, 2000).
HACSG  listed in the restricted list.
usage limits 2760--2002 GB (calculate in p-hydroxybenzoic acid; g/kg):
fresh fruit and vegetable 0.012; vinegar 0.10; carbonated beverages 0.20; fruit juice (fruit flavor) type beverages, jam (excluding canned), soy sauces 0.25; pastry stuffing 0.5 (the total amount of single use or mixed use with ethyl 4-hydroxybenzoate); egg yolk filling 0.20.
Another provision that sodium methylparaben is also equivalent application.
FAO/WHO (1984): Jam and jelly, 1000 mg/kg
FDA § 184.1670 (2000): 0.1%.
EEC(1990, mg/kg): Frozen drinks 160; beet pickled vegetables, salad dressings, 250; fragrance, fruit tarts, purees, concentrated soft drinks, 800; Fruit canned, salted fish, 1000.
Japan (calculate in p-hydroxybenzoic acid, g/kg; this product, g):
soy sauce 0.25g/L (this product 0.32); vinegarsoysoy 0.1g/L (This product 0.13); soft drinks and syrup 0.1 (this product 0.13); fruit sauce 0.2 (this product 0.26); fruits and vegetables 0.012 (this product 0.015).
Production methods This product can be derived from the esterification of p-hydroxybenzoic acid and n-propanol. First mix p-hydroxybenzoic acid with propanol and heat to dissolve. Then add sulfuric acid slowly and continue to heat for 8h of refluxion. After cooling, pour them into the 4% sodium carbonate solution for precipitation and crystallization. Filtrate and wash to neutral to obtain the crude product. After further ethanol recrystallization, the finished products are obtained. In the preparation, the cation exchange resin can be used in place of the sulfuric acid catalyst.
It can be derived from the esterification of p-hydroxybenzoic acid and n-propanol in the presence of sulfuric acid.
Add p-hydroxybenzoic acid and n-propanol in turn to the esterification reactor, and heat to dissolve. Add concentrated sulfuric acid slowly and heat for 8h of refluxion. Pour the reaction solution into 4% sodium carbonate solution before it is cooled. Constantly stir for precipitation and crystallization. Then the crude product can be obtained after centrifugal filtration and washed to neutral. Finally the finished product is acquired after activated carbon decolorization and ethanol recrystallization. The method of preparing ethyl p-hydroxybenzoate can also be used as a reference.
HOC6H4COOH + C3H7OH [H2SO4] → HOC6H4COOC3H7 + H2O
Hazards & Safety Information Category: Toxic substances
Toxicity classification :Moderate toxicity
Acute Toxicity :Celiac-mouse LD50: 200 mg/kg
Flammable hazardous characteristics :Flammable; excrete acrid and pungent smoke from fire
Storage and transport characteristics :Stored in the low-temperature, well-ventilated and dry warehouse
Fire extinguishing agent :water, carbon dioxide, dry powder, sand
Chemical Properties white crystalline powder
Uses An antimicrobial
Definition ChEBI: The benzoate ester that is the propyl ester of 4-hydroxybenzoic acid. Preservative typically found in many water-based cosmetics, such as creams, lotions, shampoos and bath products. Also used as a food additive.
Uses Pharmaceutic aid (antifungal). Antimicrobial preservative in foods and cosmetics.
General Description Colorless crystals or white powder or chunky white solid. Melting point 95-98°C. Odorless or faint aromatic odor. Low toxicity, Tasteless (numbs the tongue). pH: 6.5-7.0 (slightly acidic) in solution.
Air & Water Reactions Water soluble [Hawley].
Reactivity Profile Maximum stability of Propylparaben occurs at a pH of 4 to 5. Incompatible with alkalis and iron salts. Also incompatible with strong oxidizing agents and strong acids .
Fire Hazard Flash point data for Propylparaben are not available; however, Propylparaben is probably combustible.
 

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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