Methimazole
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1G
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NameMethimazole
- CAS No.60-56-0
- EINECS No.200-482-4
- MFC4H6N2S
- MW114.17
- InChIKeyPMRYVIKBURPHAH-UHFFFAOYSA-N
- AppearanceCrystalline PowderWhite to slightly cream or pale buff
- Boiling point 280 °C
- Melting point 144-147 °C (lit.)
- Water Solubility soluble
- storage temp. 2-8°C
- density 1.176 (estimate)
AD68
| Methimazole Basic information |
| Product Name: | Methimazole |
| Synonyms: | 1,3-dihydro-1-methyl-2h-imidazole-2-thion;1,3-dihydro-1-methyl-2H-Imidazole-2-thione;1-methyl-2-mercapto-imidazol;1-methyl-imidazole-2-thio;1-Metylo 2 merkaptoimidazolem;1-metylo2merkaptoimidazolem;2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-;2H-Imidazole-2-thione,1,3-dihydro-1-methyl- |
| CAS: | 60-56-0 |
| MF: | C4H6N2S |
| MW: | 114.17 |
| EINECS: | 200-482-4 |
| Product Categories: | Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;Heterocyclic Building Blocks;Imidazoles;M;API;TAPAZOLE;Other APIs;Medicine Intermediates;Pharmaceutical intermediates |
| Mol File: | 60-56-0.mol |
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| Methimazole Chemical Properties |
| Melting point | 144-147 °C(lit.) |
| Boiling point | 280 °C |
| density | 1.176 (estimate) |
| refractive index | 1.5000 (estimate) |
| Fp | 280°C |
| storage temp. | Refrigerator |
| solubility | 200g/l |
| form | Crystalline Powder |
| color | White to slightly cream or pale buff |
| Water Solubility | soluble |
| Merck | 14,5971 |
| BRN | 108646 |
| CAS DataBase Reference | 60-56-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Methimazole(60-56-0) |
| EPA Substance Registry System | 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-(60-56-0) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 43-62-63-22 |
| Safety Statements | 26-27-36-45-36/37 |
| WGK Germany | 3 |
| RTECS | NI8615000 |
| TSCA | Yes |
| HS Code | 29332990 |
| Hazardous Substances Data | 60-56-0(Hazardous Substances Data) |
| Methimazole Usage And Synthesis |
| description | Methimazole is an antithyroid medication used in the therapy of hyperthyroidism and Graves disease. It works by making it harder for the body to make thyroid hormone. It is also known as thiamazole, is a thioamide and a thyroid hormone antagonist which acts by inhibiting the incorporation of iodine into tyrosyl residues of thyroglobulin and, thus, lowering thyroid hormone levels. It resembles propylthiouracil both in chemical structure and activity. Methimazole is primarily used for the treatment of hyperthyroidism, by inhibiting the peroxidase system, hindering thyroxine (T4) and tri-triiodothyronine (T3) synthesis, animal experiments show that it can inhibit B lymphocytes synthesizing antibodies, and reduce levels of thyroid stimulating antibodies in blood circulating it can make suppressing T cell function return to normal, it is applicable to hyperthyroidism caused by a variety of factors . Like other various drugs (propylthiouracil), it also has some adverse reactions while it is taken, Including hematologic adverse reactions, primarily neutropenia, hematopoietic dysfunction or disorder, thrombocytopenia, reduction of prothrombin or factor VII ; long-term medication can also cause liver damage,such as cholestatic jaundice and toxic hepatitis ; other skin reactions such as hair loss, itching, rash, dermatitis, lupus erythematosus, as well as some other rare adverse reactions. Also methimazole allows prothrombin time to prolong , and increases serum alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT)and causes blood bilirubin and blood lactate dehydrogenase increasing. Therefore, patients in the medication should regularly take blood tests, liver function tests and peripheral blood leukocytes. The above information is edited by the Chemicalbook of Tian Ye. |
| Chemical properties | leaf-shaped crystalline (ethanol), melting point 146-148 ℃, boiling point 280 ℃ (decomposition), soluble in water, soluble in alcohol, chloroform, slightly soluble in ether, benzene. |
| Uses | Carbimazole intermediates. anti-thyroid drugs. |
| Production methods | React amino acetal with methyl isothiocyanate to genarate this product. The product can also be produced from thiocyanate and N-substituted amino acetal. |
| Chemical Properties | White Solid |
| Uses | Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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