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Olanzapine
Olanzapine

Olanzapine

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameOlanzapine
  • CAS No.132539-06-1
  • EINECS No.603-618-4
  • MFC17H20N4S
  • MW312.43
  • Appearancepowderyellow
  • Melting point 195°C
  • storage temp. 2-8°C
  • Boiling point 476.0±55.0 °C(Predicted)
  • density 1.32±0.1 g/cm3(Predicted)

AD68

Olanzapine Basic information
Antipsychotics Chemical properties Uses Production method
Product Name: Olanzapine
Synonyms: 3-b)(1,5)benzodiazepine,2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno(;Oltal;2-Methyl-4-(4-Methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiaze;Olanzapine (LY170053);10H-Thieno[2,3-b][1,5]benzodiazepine, 2-Methyl-4-(4-Methyl-1-piperazinyl)-;Olanzapine solution;Olanzapine for system suitability;Olanzapine, >=99%
CAS: 132539-06-1
MF: C17H20N4S
MW: 312.43
EINECS: 200-835-2
Product Categories: API;ZYPREXA;Other APIs;Active Pharmaceutical Ingredients;APIs;Olanzapine;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Heterocycles;Sulfur & Selenium Compounds
Mol File: 132539-06-1.mol
Olanzapine Structure
 
Olanzapine Chemical Properties
Melting point  195°C
Fp  2℃
storage temp.  -20°C Freezer
solubility  DMSO: >15mg/mL
color  yellow
Merck  14,6822
CAS DataBase Reference 132539-06-1(CAS DataBase Reference)
NIST Chemistry Reference Olanzapine(132539-06-1)
 
Safety Information
Hazard Codes  Xi,Xn,F
Risk Statements  36/38-36-20/21/22-11
Safety Statements  26-36/37-16
RIDADR  UN 2811 6.1 / PGIII
RTECS  XJ9007750
HazardClass  6.1
PackingGroup  III
Olanzapine Usage And Synthesis
Antipsychotics Olanzapine also known as olanzapine, olanzapine Oran, is a common antipsychotic drugs, clinically used to control schizophrenia, bipolar mania and agitation symptoms of dementia, it can significantly improve schizophrenia negative (for example: apathy, emotional and social withdrawal, poverty of speech), positive symptoms (such as: delusions, hallucinations, thought disorder, hostility and suspicion), and it may also relieve common secondary schizophrenia and related disorders affective symptoms. 
Good oral absorption, it needs 5-8 hours to reach the peak plasma concentration, and it is not affected by eating, it is metabolized in the liver through a combination of oxidation ; the major circulating metabolite is the 10-N-glucuronide. 
Animal experiments show that olanzapine displays affinity on multiple receptors 5-HT, dopamine D, α-adrenergic, histamine H et , the affinity with 5-HT2 receptor in vitro and in vivo is greater than its affinity for dopamine D2 receptors.
Animal behavior studies show that olanzapine has a 5-HT, dopamine, and cholinergic antagonism effect, and it is consistent with its receptor binding situation.
Electrophysiological studies show that olanzapine selectively reduces the limbic system (A10) dopaminergic neurons discharge, while the effect on the striatal (A9) motor path function is very small. In the reaction below to produce froze dosage levels, it can reduce the conditioned avoidance response. Different with other antipsychotics, olanzapine increases the anxiolytic response in test .
The above information is edited by the chemicalbook of Tian Ye.
Chemical properties Crystallization from acetonitrile, melting point of 195 ℃.
Uses Used to control schizophrenia, bipolar mania and other diseases
Production method 4-amino-2-methyl-10H-thieno [2,3-b] [1,5] benzo-diazepin-hydrochloride and N-methylpiperazine in toluene and dimethylsulfoxide , reflux under nitrogen for 20h, to obtain olanzapine.
Chemical Properties Yellow Crystalline Powder
Uses A serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic.
Uses intermediate for Imidacloprid, Indobufen, Nitroguanidine, Nalorphine, Tazarotene, Trovafloxacin
Uses anti-ulcer, gastrointestinal-emptying agent enhances motility in the upper gastrointestinal tract
Definition ChEBI: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
 

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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