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8-Methoxypsoralen
8-Methoxypsoralen

8-Methoxypsoralen

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product Name8-Methoxypsoralen
  • CAS No.298-81-7
  • EINECS No.206-066-9
  • MFC12H8O4
  • MW216.19
  • InChIKeyQXKHYNVANLEOEG-UHFFFAOYSA-N
  • AppearanceNeedle-Like Crystals or Powderwhite to yellow
  • Melting point 148-150 °C(lit.)
  • Water Solubility PRACTICALLY INSOLUBLE
  • storage temp. Sealed in dry,Room Temperature
  • Boiling point 276.6°C (rough estimate)
  • density 1.1344 (rough estimate)

AD68

8-Methoxypsoralen Basic information
Description References
Product Name: 8-Methoxypsoralen
Synonyms: 2-g)(1)benzopyran-7-one,9-methoxy-7h-furo(;2-g][1]benzopyran-7-one,9-methoxy-7h-furo[;5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone;5-Benzofuranacrylicacid,6-hydroxy-7-methoxy-,δ-lactone;6-Hydroxy-7-methoxy-5-benzofuranacrylic acid gamma-lactone;6-hydroxy-7-methoxy-5-benzofuranacrylicaciddelta-lactone;6-hydroxy-7-methoxy-5-benzofuranacrylicacidelta-lactone;7-Furocoumarin
CAS: 298-81-7
MF: C12H8O4
MW: 216.19
EINECS: 206-066-9
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Cytochrome P450 isozyme;This product is manufactured in GMP workshop.;Aromatics;Heterocycles;API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;OXSORALENE;Other APIs;Inhibitors
Mol File: 298-81-7.mol
8-Methoxypsoralen Structure
 
8-Methoxypsoralen Chemical Properties
Melting point  148-150 °C(lit.)
Boiling point  276.6°C (rough estimate)
density  1.1344 (rough estimate)
refractive index  1.4270 (estimate)
storage temp.  -20°C Freezer, Under Inert Atmosphere
solubility  H2O: slightly soluble
form  Needle-Like Crystals or Powder
color  white to yellow
Water Solubility  PRACTICALLY INSOLUBLE
Merck  14,5988
BRN  196453
CAS DataBase Reference 298-81-7(CAS DataBase Reference)
NIST Chemistry Reference Methoxsalen(298-81-7)
EPA Substance Registry System 7H-Furo[3,2-g][1] benzopyran-7-one, 9-methoxy-(298-81-7)
 
Safety Information
Hazard Codes  Xn,T
Risk Statements  22-43-46-45-34
Safety Statements  36/37-53-45-36/37/39-26
RIDADR  3216
WGK Germany  3
RTECS  LV1400000
F  10
TSCA  Yes
Hazardous Substances Data 298-81-7(Hazardous Substances Data)
Toxicity LD50 i.p. in rats: 470 ±30 mg/kg (Hakim)
8-Methoxypsoralen Usage And Synthesis
Description 8-methoxypsoralen (also known as methoxsalen) is a naturally occurring furocoumarin compound existing in several species of plants such as Psoralea corylifolia. It is a photoactive substance that can form DNA adducts upon UVA irradiation. It is a drug used for the treatment of psoriasis, eczema, vitiligo, and some kinds of cutaneous lymphomas associated with the exposure of skin to the UVA or light from lamps or sunlight. Its mechanism of action is through inhibiting the synthesis of the deoxyribonucleic acid (DNA). After the activation, it can preferentially bind to the guanine and cytosine molecules of DNA, further leading to the cross-linking of DNA, thus inhibiting the DNA synthesis. It can further inhibit the RNA and protein synthesis at high concentration. It is extracted from Ammi majus.
Chemical Properties Crystalline Solid
Uses antipsoriatic, pigmentation agent
Uses Naturally occurring analog of Psoralen (P839800). Use in treatment of psoriasis and mycosis fungoides.
Uses For the treatment of psoriasis and vitiligo
Uses Naturally occurring analog of psoralen. Use in treatment of psoriasis and mycosis fungoides
Uses A potent suicide inhibitor of cytochrome P-450.
Definition ChEBI: A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
General Description Odorless white to cream-colored crystalline solid. Bitter taste followed by tingling sensation.
Air & Water Reactions Sensitive to light and air. Insoluble in water.
Reactivity Profile 8-Methoxypsoralen is incompatible with strong oxidizing agents.
Fire Hazard Flash point data for 8-Methoxypsoralen are not available; however, 8-Methoxypsoralen is probably combustible.
 

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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career henan chemical co

Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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