Disodium phosphonomycin

Price	USD1.00
Packge	1KG

Min. Order:1G
Supply Ability:100KG
Time:2019-07-06

Product Details

Product NameDisodium phosphonomycin
CAS No.26016-99-9
EINECS No.247-409-2
MFC3H8NaO4P
MW162.06
AppearanceneatWhite to Off-White
storage temp. Inert atmosphere,2-8°C
Melting point >300°C
Water Solubility Freely soluble in water or aqueous solution

AD68

Disodium phosphonomycin Basic information

Appearance Properties Pharmacological effects Indications Usage and dosage Combination therapy Detection Indicator Precautions Uses

Product Name:	Disodium phosphonomycin
Synonyms:	[(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid disodium salt;Fosfomycin sodium;disodium [(2R,3S)-3-methyloxiran-2-yl]-bis(oxidanidyl)-oxo-$l^{5}-phosphane;disodium [(2R,3S)-3-methyloxiran-2-yl]-dioxido-oxo-$l^{5}-phosphane;disodium keto-[(2R,3S)-3-methyloxiran-2-yl]-dioxido-phosphorane;Sodium ((2S,3R)-3-methyloxiran-2-yl)phosphonate;2S)-1;(1,2-epoxypropyl)-,disodiumsalt(1r,2s)(-)-phosphonicaci
CAS:	26016-99-9
MF:	C3H5Na2O4P
MW:	182.02
EINECS:	247-409-2
Product Categories:	API;antibiotic;Antibiotics;chiral;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;Peptide Synthesis/Antibiotics
Mol File:	26016-99-9.mol

Disodium phosphonomycin Chemical Properties

Melting point	>300°C
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL, clear, colorless
Water Solubility	Freely soluble in water or aqueous solution
CAS DataBase Reference	26016-99-9(CAS DataBase Reference)

Safety Information

Hazard Codes	F,C
Risk Statements	11-34
Safety Statements	16-26-36/37/39-45
WGK Germany	2
RTECS	SZ7902000
F	10-21

Disodium phosphonomycin Usage And Synthesis

Appearance Properties	It appears as a white crystalline powder at room temperature, hygroscopic, easily soluble in water, heated while dissolving. Fosfomycin Sodium can combine with a bacterial cell wall synthesis enzyme, hinder bacterial cell wall synthesis related substances utilizing at the first reaction, which in turn has a bactericidal effect. have antibacterial effect for Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Neisseria gonorrhoeae, Proteus mirabilis, Salmonella typhi, Serratia bacteria, most Pseudomonas aeruginosa, Streptococcus pyogenes, Streptococcus faecalis, part indole-positive Proteus and certain Klebsiella, Enterobacter bacteria. The main clinical applications of Fosfomycin Sodium include: urinary tract treatment of sensitive Gram-negative bacteria caused urinary system, infection of skin and soft tissue, respiratory, intestinal and other parts. It can also be combined with other antibiotics, the treatment of severe infections caused by susceptible strains such as sepsis, pulmonary, meningeal infections, peritonitis, adnexitis, intrauterine infections, pelvic inflammatory disease, osteomyelitis. Also in combination with vancomycin for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection.
Pharmacological effects	1. Broad spectrum antibiotic, high bioavailability, rapid absorption, strong anti-bacterial, not diet affected. Fosfomycin Sodium displays effects on killing Gram-positive and Gram-negative bacteria, especially Pseudomonas aeruginosa, Proteus, Salmonella, and exhibit excellent antibacterial activity for a variety of drug-resistant Staphylococcus aureus and Escherichia coli. For usage in animals, there is no drug resistance and cross-resistance. Clinical effect is good. 2. Rapid sterilization: This product is a rapid fungicide, its role is still evident after 1-2 hours. About 25% of the E. coli were killed at 1 hour after exposured to Fosfomycin Sodium (12.5μg/ml), and all died within 4-6 hours. Pseudomonas aeruginosa and Staphylococcus aureus were also all killed at 4 and 8 hours. 3. Low toxicity, little irritation on the body, no acute toxicity and adverse reactions, no increased burden on the kidney. 4. Low residue: the eliminate time for the muscles and organs to reach the residual standard is 48-72 hours. The above information is edited by the Chemicalbook of Tian Ye.
Indications	Mainly used for Staphylococcus aureus, streptococcus, E. coli, Salmonella and other gram-negative bacteria caused acute and chronic bowel disease treatment in chickens, ducks, pigs.
Usage and dosage	Used in water for livestock and poultry: every 100kg of water added the product 5-10 grams, 2 times a day, once every three days. Used in animal spices: 10-15 g of the product added to per 100kg feed, 2 times a day, once every three days.
Combination therapy	For the treatment of intestinal infections, Fosfomycin Sodium can combine with β-lactam, aminoglycoside. For the treatment of respiratory and lung infections, combining with macrolides, β-lactam. For staph infections, better combined with erythromycin, rifampin. For the treatment of acute respiratory infections, sepsis, peritonitis ect., increase the dose. Need to combine with β-lactams or aminoglycosides.
Detection Indicator	No. Test item Export standard CP2000 Edition 1 Traits: A white crystalline powder, odorless, taste salty white crystalline powder, odorless, salty taste 2 Discriminator: Positive reaction Positive reaction 3 Specific rotation °-4.2 ~-5.5-4.2 ~-5.5 4 Heavy Metal ≤0.0010% 0≤.0010% 5 Content ≥700μ/mg ≥700μ/mg 6 Alkalinity 9.0-10.5 9.0-10.5 7 Weight loss on drying ≤1.0% ≤1.5% (water) 8 Solution clarity ≤No. 3/4 turbidity standards solution ≤No. 1 turbidity standard solution 9 Color of the solution ≤Yellow No. 1 ≤ Yellow No. 1 10 Glycols ≤0.50% ≤0.50% 11 Clarity of solution: can not be detected, in compliance with (a gross point ≤8/g, wherein a color point ≤2/g) 12 W ≤0.002%- 13 phosphorus content-16.2-17.9% 14 Sterile: Subject to compliance 15 Heat source/ bacterial endotoxin: compliance (heat source) compliance (bacterial endotoxin) 16 α-phenylethylamine ≤0.01%- 17 Residual amount of methanol: real 18 Residual amount of ethanol: Real The above information is the main export detection index of fosfomycin.
Precautions	1. This product is mainly used for pigs, chickens, fish; application for other animals should medication under veterinary guidance. 2. Fosfomycin Sodiumand β-lactams, aminoglycosides, macrocyclic acid esters have a synergistic effect of combination therapy, and can reduce or delay the occurrence of bacterial resistance.
Uses	For the treatment of infections caused by Staphylococcus aureus, Escherichia coli, Proteus and Shigella.
Chemical Properties	White Solid
Uses	Curariform muscle relaxants
Uses	Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

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career henan chemical co

Henan China

Since:2014-12-17
Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho

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